Biomarkers for Bipolar Disorder: Chaperones and Reticulum Endoplasmatic Stress Response CHAP´s Study (CHAPS)

This study has suspended participant recruitment.
(fail to get funding)
Sponsor:
Information provided by:
University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT00994630
First received: October 13, 2009
Last updated: August 15, 2011
Last verified: May 2011
  Purpose

The purpose of this study is to determine expression of chaperones proteins from the endoplasmatic reticulum stress response system in bipolar I patients (manic phase) compared to healthy controls.

Hypothesis: There is no difference in chaperones proteins expression between bipolar I manic patients and healthy controls


Condition
Bipolar Disease Type I

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Biomarkers for Bipolar Disorder: Chaperones and Reticulum Endoplasmatic Stress Response CHAP´s Study

Resource links provided by NLM:


Further study details as provided by University of Sao Paulo:

Biospecimen Retention:   Samples With DNA

Dna and Rna analysis


Estimated Enrollment: 20
Study Start Date: January 2010
Estimated Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
BP I patients manic phase

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Bipolar Disease type I manic phase

Criteria

Inclusion Criteria:

  • Bipolar Disease type I manic phase
  • YMRS > 14
  • HDRS < 9

Exclusion Criteria:

  • Use of lithium, divalproate, or carbamazepine in therapeutic levels over the past 30 days
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00994630

Locations
Brazil
Mood Disorders Program, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo
Sao paulo, Brazil
Sponsors and Collaborators
University of Sao Paulo
Investigators
Principal Investigator: Ricardo A Moreno, MD, PhD Mood Disorders Program, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
Study Director: Marcio G Soeiro de Souza, MD Mood Disorders Program, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
  More Information

No publications provided

Responsible Party: Ricardo Alberto Moreno, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT00994630     History of Changes
Other Study ID Numbers: CHAPS STUDY
Study First Received: October 13, 2009
Last Updated: August 15, 2011
Health Authority: Brazil: National Committee of Ethics in Research

Additional relevant MeSH terms:
Bipolar Disorder
Affective Disorders, Psychotic
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on September 15, 2014