Leukemia Cell Cultures for Research of New Anti-Cancer Therapies
This study is currently recruiting participants.
Verified August 2011 by University Hospital, Strasbourg, France
Sponsor:
University Hospital, Strasbourg, France
Information provided by:
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT00993538
First received: October 9, 2009
Last updated: August 29, 2011
Last verified: August 2011
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Purpose
The main objective of this project is not only a better understanding of the human leukemic disease but also to find new anti-leukemic or improve existing ones. This study has, the following aims:
- To analyze the genetic and epigenetic regulation of the retinoic acid induced cascade which leads to the expression of TRAIL in blood cells of patients with acute leukemia. This study will be complemented by the analysis of global gene expression (DNA chips) and of the DNA methylation state, and by chromatin immunoprecipitation experiences.
- To determine the efficiency of inhibitors of enzymes responsible for the modification of chromatin (existing and new developments within the European consortium EPITRON coordinated by Dr Gronemeyer) as inducers of differentiation and / or apoptosis of leukemic blasts.
- To explore Ikaros genic and functional abnormalities (genomic deletions, mutations, abnormal transcripts and proteins) in acute leukemia. The aim is to determine if these abnormalities may play a prognosis role.
| Condition | Intervention |
|---|---|
|
Acute Leukaemia |
Procedure: Blood sampling Procedure: Bone marrow aspiration |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Basic Science |
| Official Title: | Leukemia Cell Cultures for Research of New Anti-cancer Therapies |
Resource links provided by NLM:
Further study details as provided by University Hospital, Strasbourg, France:
| Estimated Enrollment: | 180 |
| Study Start Date: | July 2009 |
| Arms | Assigned Interventions |
|---|---|
| Experimental: 1 | Procedure: Blood sampling Procedure: Bone marrow aspiration |
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Patients with suspected de novo or secondary or relapsed acute leukemia, requiring complementary blood test and bone marrow analysis
- Patients older or equal than 28 days
- Informed consent signed
Exclusion Criteria:
- Pregnancy
- Breastfeeding
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00993538
Contacts
| Contact: Raoul Herbrecht, MD | 3.33.88.12.83.79 | Raoul.herbrecht@chru-strasbourg.fr |
| Contact: Patrick lutz, MD | 3.33.88.12.80.90 | Patrick.lutz@chru-strasbourg.fr |
Locations
| France | |
| Service d'Hématologie et d'Oncologie | Recruiting |
| Strasbourg, France, 67098 | |
| Contact: Raoul Herbrecht, MD 3.33.88.12.83.79 Raoul.herbrecht@chru-strasbourg.fr | |
| Principal Investigator: Raoul Herbrecht, MD | |
| Sub-Investigator: Cécile Fohrer, MD | |
| Sub-Investigator: Luc Fornecker, MD | |
| Sub-Investigator: Bruno Lioure, MD | |
| Sub-Investigator: Karin Bilger, MD | |
| Service de Pédiaterie - Hôpital de Hautepierre | Recruiting |
| Strasbourg, France, 67098 | |
| Contact: Patrick Lutz, MD 3.33.88.12.80.90 Patrick.lutz@chru-strasbourg.fr | |
| Principal Investigator: Patrick Lutz, MD | |
| Sub-Investigator: Natacha Entz-Werle, MD | |
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
| Principal Investigator: | Raoul Herbrecht, MD | Département d'Hématologie et d'Oncologie-hôpital de Hautepierre Strasbourg, France |
More Information
No publications provided
| Responsible Party: | Christine GEILLER/Directeur de la Recherche Clinique et des Innovations, University Hospital, Strasbourg, France |
| ClinicalTrials.gov Identifier: | NCT00993538 History of Changes |
| Other Study ID Numbers: | 4452 |
| Study First Received: | October 9, 2009 |
| Last Updated: | August 29, 2011 |
| Health Authority: | France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis) |
Keywords provided by University Hospital, Strasbourg, France:
|
Leukaemia Blood and marrow cells culture Cell growth Cell differentiation |
Additional relevant MeSH terms:
|
Leukemia Neoplasms by Histologic Type Neoplasms |
ClinicalTrials.gov processed this record on May 16, 2013