Mechanisms Defending Fat Mass in Humans After Lipectomy
Liposuction surgery is common, yet animal and limited human data suggest that fat returns when removed. We undertook a 1-year randomized-controlled trial of suction lipectomy versus no intervention to determine if adipose tissue is defended, and if so to determine the anatomic pattern of redistribution.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Mechanisms Defending Fat Mass in Humans After Lipectomy|
- Body composition changes measured by DXA. [ Time Frame: Baseline, 6wks, 6mos, 1-year ] [ Designated as safety issue: No ]
|Study Start Date:||April 2004|
|Study Completion Date:||November 2008|
|Primary Completion Date:||November 2008 (Final data collection date for primary outcome measure)|
No Intervention: Control
- To determine if suction lipectomy fails to modify regional and/or total body fat over three years.
- To determine if the expression of candidate genes predicts and/or relates to subcutaneous adipose tissue growth or depletion in subcutaneous adipose tissue after suction lipectomy.
- To examine adipose tissue before and after suction lipectomy to uncover novel genes where expression predicts and/or relates to subcutaneous adipose tissue growth or depletion after subcutaneous suction lipectomy.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00993213
|United States, Colorado|
|University of Colorado Denver|
|Aurora, Colorado, United States, 80045|
|Principal Investigator:||Robert H Eckel, MD||University of Colorado, Denver|