Diabetes Prevention In Estrie

• a weight loss of 7% in at least 19% of the subjects [ Time Frame: one year ] [ Designated as safety issue: No ]
  
• reduced body weight of at least 5.6 kg in at least 25% of the subjects [ Time Frame: one year ] [ Designated as safety issue: No ]
  
• an increase in the level of physical activity by at least 150 minutes per week in at least 29% of the subjects [ Time Frame: one year ] [ Designated as safety issue: No ]
  
• a reduced daily caloric intake of at least 450 kcal/jour in at least 25% of the subjects [ Time Frame: one year ]
  
• a reduced percentage of the calories introduced in the form of fat of at least 6.6%, in absolute value, in at least 25% of the subjects [ Time Frame: one year ] [ Designated as safety issue: No ]
  

• change in insulin sensitivity by HOMA [ Time Frame: one year ] [ Designated as safety issue: No ]
  
• change in insulin secretion during an OGTT by deconvolution of plasma c-peptide [ Time Frame: one year ] [ Designated as safety issue: No ]
  
• change in beta cell function by calculation of the disposition index [ Time Frame: one year ] [ Designated as safety issue: No ]
  
• change in insulin-mediated suppression of plasma non-esterified fatty acids during an OGTT [ Time Frame: one year ] [ Designated as safety issue: No ]
  
• relation between weight loss and change in insulin sensitivity, beta cell function, and insulin-mediated suppression of plasma non-esterified fatty acids [ Time Frame: one year ] [ Designated as safety issue: No ]
  

Eligible participants will be randomized into 2 intervention groups (30 per group):

1. Small Meeting groups: a curriculum of 25 meeting-seminars will take place for 45 minutes, each one approaching various aspects of nutrition, physical activity, psychology, motivation and medical needs. These seminars are administered by the professionals of the obesity clinic and are already in place. However, these are usually only offered to the patients registered with the obesity clinic.
2. Obesity Clinic of CHUS: combination of 25 described meeting-seminars see-high, in addition to individual interviews every 6 weeks with the interdisciplinary team of the obesity clinic of CHUS (usual operation).

Subjects will be evaluated initially and then every 3 months during 1 year by the following measurements: questionnaires to evaluate motivation and physical activity; 3 day dietary journals; weight assessment, using both metabolic and mechanical balance; waist circumference; and blood pressure.

A medical evaluation with size measure, a test evaluating knowledge of the participants on obesity, OGTT (Oral Glucose Tolerance Test) - a 5 hour determination of secretion and resistance to insulin, insulin-mediated suppression of plasma non-esterified fatty acids, a plasma lipid profile, accelerometry, bio electric impedance, and an activity physical test (6 minute walk test) will be carried out initially, and then repeated for up to 1 year.