Collagen Analysis and Genetic Analysis of Families With Tendency to Hernias
Recruitment status was Recruiting
Analysis of collagen subtype subcutaneously and genetic analysis of patients from families with a tendency to hernias. Furthermore circulating biomarkers and biomarkers extracted from the subcutaneously tissue such as MMP's (matrix metallo proteinases) and TIMP's (tissue inhibitor of metallo proteinases) will be measured.
|Study Design:||Observational Model: Family-Based
Time Perspective: Prospective
|Official Title:||Collagen-subtype Analysis in Subcutaneous Tissue and Genetic Analysis on Patients From Families With a Tendency to Hernias|
- Expression of collagen-genes or other relevant genes by microarray analysis compared with presence of hernia [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
- Amount of collagen subtypes measured subcutaneously. [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
Biospecimen Retention: Samples With DNA
blood samples and subcutaneous tissue
|Study Start Date:||December 2009|
|Estimated Study Completion Date:||June 2011|
|Estimated Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
|individuals from hernia-family|
Research has shown relationship between hernias and collagen subtype I/III ratio, biomarkers such as MMP's TIMP's and other diseases such as Ehlers-Danlos, Marfans syndrome, AAA (abdominal aortic aneurysms), diverticulosis and rectal prolapse. Furthermore has research raised hypothesis about inheritance of hernias. The investigators are performing genetic examination combined with analysis of collagen and biomarkers on patients belonging to families with tendency to hernias.
Other examinations performed on the patients enrolled in this study:
- Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms.
- Beightons score to evaluate the degree of joint hypermobility.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00991484
|Contact: Jakob Burcharth, MD||0045 44884488 ext firstname.lastname@example.org|
|DK-2730, Herlev, Herlev, Denmark, 2730|
|Contact: jakob Burcharth, MS 004544884488 email@example.com|
|Principal Investigator: Jakob Burcharth, MD|
|Study Director:||Jacob Rosenberg, Prof. MD||Herlev Hospital|
|Principal Investigator:||Jakob Burcharth, MD||Herlev Hospital|