Comparison of Central Venous Pressures (CVPs) Measured From Peripherally Inserted Central Catheters (PICC) and CICC in Liver Transplantation Recipients

This study has been completed.
Sponsor:
Information provided by:
National Cancer Center, Korea
ClinicalTrials.gov Identifier:
NCT00988871
First received: October 1, 2009
Last updated: NA
Last verified: October 2009
History: No changes posted
  Purpose

Background: Central venous pressure (CVP) monitoring from the peripherally inserted central venous catheter (PICC) has not often been used because of the higher inherent resistance of the PICC due to its longer length and narrower lumen. The objective of this study was to assess the reliability of the CVP measured from PICCs as a predictor of the CVP measured from CICCs in the setting of rapidly fluctuating hemodynamic conditions during liver transplantation.


Condition Intervention
Patients Cannulated With Both PICC and CICC.
The Rapidly Fluctuating Hemodynamics During LT.
Device: PICC, CICC

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Comparison of the Central Venous Pressures Measured From the Peripherally Inserted Antecubital Central Catheters and the Internal Jugular Vein Central Catheters in Liver Transplantation Recipients

Resource links provided by NLM:


Further study details as provided by National Cancer Center, Korea:

Primary Outcome Measures:
  • PICCP: CVP measured from peripherally inserted antecubital central catheters in liver transplantation recipients [ Time Frame: every 10 minutes during the liver transplantation ] [ Designated as safety issue: No ]
  • CICCP: CVP from IJV central catheters in liver transplantation recipients [ Time Frame: every 10 minutes during the liver transplantation ] [ Designated as safety issue: No ]

Enrollment: 35
Study Start Date: August 2008
Study Completion Date: June 2009
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Liver transplantation (LT) recipients
LT recipients who had both PICC and CICC at the same time according to the LT protocol of our hospital
Device: PICC, CICC
PICC insertion, CICC (advanced venous access with pulmonary artery catheter) insertion

Detailed Description:

According to the protocol of LT in our hospital, a PICC is concomitantly inserted with the pulmonary artery catheter (PAC) and 9-Fr advanced venous access (AVA) catheter for the LT recipient at anesthetic induction. PAC and AVA catheter are usually removed on the second postoperative day, and instead the PICC is used for the postoperative infusion of prostaglandin E1 which is very irritable to small peripheral vein. So we fortunately had chance to measure the CVPs from both CICC and PICC simultaneously in the same patients.

Methods: We measured the CVPs from the CICC and the PICC simultaneously during each main surgical period of adult liver transplantation (preanhepatic, anhepatic, reperfusion, and neo-hepatic period). Data are presented as means ± standard deviation. Statistical analysis was performed using simple linear regression analysis to observe whether changes in the PICCP were paralleled by simultaneous changes in the CICCP. Bland-Altman analysis was used to determine the degree of agreement between the two devices. Analysis of variance was performed to study whether there were changes in the CVP agreement profiles in regard to the different time periods of LT. Differences were regarded as being statistically significant when p values were less than 0.05.

(This observational study has been completed already.)

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Adult patients who had been scheduled for elective liver transplant surgery, and placed with both PICC and CICC.

Criteria

Inclusion Criteria:

  • Adult patients who had been scheduled for elective liver transplant surgery
  • Patients who had been placed with both PICC and CICC at anesthetic induction

Exclusion Criteria:

  • Failure to insert PICC
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00988871

Locations
Korea, Republic of
National Cancer Center
323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769
Sponsors and Collaborators
National Cancer Center, Korea
Investigators
Study Director: So-Hee Park, PhD Department of cancer registration and biostatistics branch, Research institute and hospital, National cancer center, Republic of Korea
Study Director: Soon-Ae Lee, MD.PhD. Department of Anesthesiology and pain medicine, Research institute and hospital, National cancer center, Republic of Korea
  More Information

Publications:
Responsible Party: Jung-Yeon Yun MD, PhD / Title: Staff anesthesiologist, Department of Anesthesiology and pain medicine, Research institute and hospital, National cancer center, Republic of Korea
ClinicalTrials.gov Identifier: NCT00988871     History of Changes
Other Study ID Numbers: PICC1342
Study First Received: October 1, 2009
Last Updated: October 1, 2009
Health Authority: Korea: Institutional Review Board

Keywords provided by National Cancer Center, Korea:
PICC (peripherally inserted central venous catheter)
CICC (centrally inserted central venous catheter
CVP (central venous pressure)
LT (liver transplantation)
agreement

ClinicalTrials.gov processed this record on August 18, 2014