Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

The recruitment status of this study is unknown because the information has not been verified recently.

Verified September 2009 by University of Aarhus. Recruitment status was Recruiting

First Received on September 16, 2009. No Changes Posted

Sponsor:	University of Aarhus
Information provided by:	University of Aarhus
ClinicalTrials.gov Identifier:	NCT00978640

Purpose

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Condition	Intervention
Healthy	Other: fast and exercise Other: exercise

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Crossover Assignment Masking: Open Label Primary Purpose: Basic Science
Official Title:	Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise

Resource links provided by NLM:

MedlinePlus related topics: Exercise and Physical Fitness

U.S. FDA Resources

Further study details as provided by University of Aarhus:

Primary Outcome Measures:

Sirt1 activity [ Time Frame: 60 min ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover. [ Time Frame: 4 h ] [ Designated as safety issue: No ]

Estimated Enrollment:	8
Study Start Date:	September 2009
Estimated Primary Completion Date:	July 2010 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: fasting and exercise 36 h fast and 1 h ergometer cycling 50% VO2max	Other: fast and exercise fasting 36 h and exercise 1 h 50% VO2max
Experimental: exercise 1 h ergometer cycling 50% VO2max	Other: exercise exercise 1 h 50% VO2max

Eligibility

Ages Eligible for Study:	18 Years to 45 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

healthy men
Body mass index (BMI) 20-26
age 18-45 years

Exclusion Criteria:

any kind of disease
any use of medicine

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00978640

Contacts

Contact: Mikkel Holm vendelbo, MD

0045 22182256

mikkel.vendelbo@ki.au.dk

Locations

Denmark
mikkel Holm Vendelbo	Recruiting
Århus, Jylland, Denmark, 8000
Contact: mikkel Holm vendelbo, MD mikkel.vendelbo@ki.au.dk

Sponsors and Collaborators

University of Aarhus

More Information

No publications provided

Responsible Party:	Mikkel Vendelbo MD, endokrinologiskforskningslaboratorium M, Aarhus sygehus
ClinicalTrials.gov Identifier:	NCT00978640 History of Changes
Other Study ID Numbers:	07.09.2009
Study First Received:	September 16, 2009
Last Updated:	September 16, 2009
Health Authority:	Denmark: Ethics Committee

Keywords provided by University of Aarhus:

Sirt1 activity

ClinicalTrials.gov processed this record on February 09, 2012