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Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00978640
First received: September 16, 2009
Last updated: June 19, 2012
Last verified: June 2012
History of Changes
  Purpose

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.


Condition Intervention
Healthy
 Other: fast and exercise
Other: exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Sirt1 activity [ Time Frame: 60 min ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover. [ Time Frame: 4 h ] [ Designated as safety issue: No ]

Estimated Enrollment: 8
Study Start Date: September 2009
Estimated Study Completion Date: June 2012
Estimated Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: fasting and exercise
36 h fast and 1 h ergometer cycling 50% VO2max
 Other: fast and exercise
fasting 36 h and exercise 1 h 50% VO2max
Experimental: exercise
1 h ergometer cycling 50% VO2max
 Other: exercise
exercise 1 h 50% VO2max

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men
  • Body mass index (BMI) 20-26
  • age 18-45 years

Exclusion Criteria:

  • any kind of disease
  • any use of medicine
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00978640

Locations
Denmark
mikkel Holm Vendelbo
Århus, Jylland, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

No publications provided

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00978640     History of Changes
Other Study ID Numbers: 07.09.2009
Study First Received: September 16, 2009
Last Updated: June 19, 2012
Health Authority: Denmark: Ethics Committee

Keywords provided by University of Aarhus:
Sirt1 activity

ClinicalTrials.gov processed this record on May 22, 2013