Correlation of Particulate Matter and Heme Oxygenase-1 Protein Activity in Asthmatic Children by Induced Sputum Analysis.
Recruitment status was Recruiting
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Purpose
Samples of sputum from asthmatic children, between 5-17 years, will be collected during two years of the study period to perform tests Particle Size Distribution (PSD) and Shape Analysis (SA) of the particulate matter in the sputum and a biochemical reaction to evaluate the activity of Heme Oxygenase-1 protein in sputum cell supernatants.
Each child will perform Pulmonary Function Testing (PFT) and Induced Sputum (IS) as a routine part of diagnosis of asthma.
Parents will be asked to complete a questionnaire including questions on their child's respiratory symptoms in the last 12 months as well as socioeconomic factors. Parents will be asked to give informed written consent for their child's participation in the study.
| Condition |
|---|
|
Asthma |
| Study Type: | Observational |
| Study Design: | Observational Model: Ecologic or Community Time Perspective: Cross-Sectional |
| Official Title: | Correlation of Particulate Matter and Heme Oxygenase-1 Protein Activity in Asthmatic Children by Induced Sputum Analysis. |
Eligibility| Ages Eligible for Study: | 5 Years to 17 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Children, between 5-17 years, performing a routine diagnosis of asthma in Tel Aviv Sourasky Medical Center
Inclusion Criteria:
- •All children, between 5-17 years, performing a routine diagnosis of asthma in Tel Aviv Sourasky Medical Center that there parents gave informed written consent for their child's participation in the study.
Exclusion Criteria:
- None.
Contacts and Locations| Israel | |
| Pulmonary Laboratory of Tel Aviv Sourasky Medical Center | Recruiting |
| Tel Aviv, Israel | |
| Contact: Elizabeth Fierman, PhD lizif@tasmc.health.gov.il | |
| Contact: Daria Bliznuk, BcS dasha_bl@yahoo.com | |
| Principal Investigator: Elizabeth Fierman, PhD | |
More Information
No publications provided
| Responsible Party: | Elizabeth Fierman, PhD, Tel-Aviv Sourasky Medical Center |
| ClinicalTrials.gov Identifier: | NCT00969670 History of Changes |
| Other Study ID Numbers: | TASMC-09-LF-242-CTIL |
| Study First Received: | August 29, 2009 |
| Last Updated: | November 21, 2009 |
| Health Authority: | Israel: Ethics Commission |
Additional relevant MeSH terms:
|
Asthma Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases |
Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases |
ClinicalTrials.gov processed this record on May 21, 2013