Adaptive Support Ventilation in the Weaning of COPD

This study has been completed.
Sponsor:
Information provided by:
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
ClinicalTrials.gov Identifier:
NCT00969605
First received: August 31, 2009
Last updated: May 26, 2010
Last verified: September 2009
  Purpose

Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both as pressure support (PSV) and pressure controlled (PCV) ventilation. Weaning with ASV shows promising results mainly in post-cardiac surgery patients. The aim of this randomized controlled study was to test the hypothesis that weaning with ASV could reduce the weaning duration in patients with chronic obstructive pulmonary disease (COPD) when compared with PSV.


Condition Intervention Phase
Pulmonary Disease, Chronic Obstructive
Procedure: Comparison of two different modes for weaning from mechanical ventilation
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Screening
Official Title: Adaptive Support Ventilation for Faster Weaning in COPD: A Randomized Controlled Trial

Resource links provided by NLM:


Further study details as provided by Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital:

Primary Outcome Measures:
  • Weaning duration [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Weaning success [ Designated as safety issue: Yes ]
  • Length of stay in the ICU [ Designated as safety issue: No ]

Enrollment: 97
Study Start Date: April 2007
Study Completion Date: December 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Pressure support ventilation Procedure: Comparison of two different modes for weaning from mechanical ventilation
Chronic obstructive pulmonary disease patients under mechanical ventilation were randomized to adaptive or pressure support ventilation modes when they met the weaning criteria.
Other Name: weaning protocol
Active Comparator: Adaptive support ventilation Procedure: Comparison of two different modes for weaning from mechanical ventilation
Chronic obstructive pulmonary disease patients under mechanical ventilation were randomized to adaptive or pressure support ventilation modes when they met the weaning criteria.
Other Name: weaning protocol

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Diagnosis of COPD
  • On invasive mechanical ventilation for at least 24 hours because of hypoxemic and/or hypercapnic respiratory failure

Exclusion Criteria:

  • Mechanical ventilation less then 24 hours (self extubation or death),
  • Having a tracheotomy and
  • COPD coexisted with severe cardiac or neurologic diseases.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00969605

Locations
Turkey
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
Izmir, Turkey, 35210
Sponsors and Collaborators
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Investigators
Study Director: Cenk Kirakli, MD Izmir Dr Suat Seren Chest Diseases and Chest Surgery Education and Research Hospital
  More Information

No publications provided

Responsible Party: Cenk Kirakli,MD, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
ClinicalTrials.gov Identifier: NCT00969605     History of Changes
Other Study ID Numbers: IGCEH-ICU-1
Study First Received: August 31, 2009
Last Updated: May 26, 2010
Health Authority: Turkey: Ministry of Health

Keywords provided by Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital:
weaning
adaptive support ventilation
COPD

Additional relevant MeSH terms:
Chronic Disease
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive
Disease Attributes
Pathologic Processes
Respiratory Tract Diseases
Lung Diseases, Obstructive

ClinicalTrials.gov processed this record on April 23, 2014