Biology of Thymic Tumors
This is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Biological Analysis of a Series of Thymoma and Thymic Carcinoma: Genetic Aberrations and Potential Therapy Targets.|
- Primary objective: to evaluate the presence of genetic alterations and specific potential therapy targets. [ Time Frame: one year ] [ Designated as safety issue: No ]
- Secondary objective: to correlate the biological characteristics with clinical characteristics and survival data of patients. [ Time Frame: one year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
paraffin-embedded tumor specimens of patients
|Study Start Date:||June 2008|
|Study Completion Date:||August 2009|
|Primary Completion Date:||August 2008 (Final data collection date for primary outcome measure)|
The aim of the present study is to investigated the genetic alterations in tumor samples of a series of all WHO-defined subtypes of thymoma patients using high resolution microarray- comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the data to identify specific patterns of genetic aberrations and genes associated with each subtype. Moreover, tumor samples will be also investigated for some specific potential therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ hybridization (FISH) analysis. All these biological data will be correlated with clinical patients characteristics and survival data.