Metabolism of Lipids in Advanced Cancer
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Purpose
The causes of failing nutrition status in advanced cancer are not well known. The way fat is moved, stored, burned or changed into other compounds may be affected and will be followed in patients using a tracer and other blood tests. The investigators hypothesize that fat loss and wasting results from low essential fatty acid availability in the body. Changes may occur in the liver that limits distribution and availability of fat to the body as an energy source or for other essential functions.
| Condition | Intervention |
|---|---|
|
Lung Neoplasms Cachexia |
Other: Blood draws Biological: Oral administration of stable isotope (deuterium) Procedure: Metabolic rate testing |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Cross-Sectional |
| Official Title: | Metabolism of Lipids in Advanced Cancer |
- Rate of hepatic de novo lipogenesis [ Time Frame: 9 months ] [ Designated as safety issue: No ]
- Measures of fat transport and availability [ Time Frame: 9 months ] [ Designated as safety issue: No ]
- Resting metabolic rate & fat oxidation [ Time Frame: 9 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Blood
| Enrollment: | 12 |
| Study Start Date: | October 2009 |
| Study Completion Date: | October 2011 |
| Primary Completion Date: | October 2011 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
Metabolism
Lung cancer patients who exhibit abnormalities in lipid measures.
|
Other: Blood draws
Up to 4 blood draws will be required, in the amount of about 10 mL each
Biological: Oral administration of stable isotope (deuterium)
1 mg deuterium-labeled water/kg body water (loading dose), and 0.5 mg/kg body water diluted in 1 L of normal water (maintenance dose) to be consumed over the following 16 hours
Other Name: C/D/N Isotopes, Deuterium Oxide, CAS No: 7789-20-0
Procedure: Metabolic rate testing
Metabolic rate testing is a painless, non-invasive test that takes about 1h. A metabolic cart is used, which detects the amount of oxygen and carbon dioxide the body uses. Patients will lie down on a bed for 30 minutes with lights dimmed and soft music to help them relax. After 30 minutes, a canopy will be placed over the patient's head and shoulders for 30 minutes for the analysis of breath samples. This test will be performed only once for this study.
|
Detailed Description:
Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves. This research will explore how people with cancer use fat in their body through the use of tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used to trace the production of different fats by the liver. Other methods will determine how much and what types of fat are transported around the body. Body composition will be determined by CT scan and related to fat measures.
Eligibility| Ages Eligible for Study: | 18 Years to 85 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Lung cancer patients
Inclusion Criteria:
- Low plasma phospholipids OR low plasma ratio of triglycerides to free fatty acids
- Recent weight loss
- Advanced stage lung cancer (Stage 3 or 4)
Exclusion Criteria:
- Having symptoms that may affect measures of fat metabolism (nausea, vomiting, problems swallowing, etc.)
- Taking n-3 fatty acid supplements such as fish oil
Contacts and Locations More Information
Additional Information:
No publications provided
| Responsible Party: | Alberta Health Services |
| ClinicalTrials.gov Identifier: | NCT00962234 History of Changes |
| Other Study ID Numbers: | CIHR PIN 111846/ethics 24906, CIHR PIN 111846 |
| Study First Received: | August 17, 2009 |
| Last Updated: | April 4, 2012 |
| Health Authority: | Canada: Health Canada |
Keywords provided by Alberta Health Services:
|
Lipogenesis Lipolysis Phospholipids |
Body Composition Nutritional Status Lipid Metabolism |
Additional relevant MeSH terms:
|
Cachexia Neoplasms Lung Neoplasms Emaciation Weight Loss Body Weight Changes Body Weight Signs and Symptoms Respiratory Tract Neoplasms Thoracic Neoplasms |
Neoplasms by Site Lung Diseases Respiratory Tract Diseases Deuterium Oxide Antineoplastic Agents Therapeutic Uses Pharmacologic Actions Radiation-Protective Agents Protective Agents Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on May 22, 2013