Metabolism of Lipids in Advanced Cancer
The causes of failing nutrition status in advanced cancer are not well known. The way fat is moved, stored, burned or changed into other compounds may be affected and will be followed in patients using a tracer and other blood tests. The investigators hypothesize that fat loss and wasting results from low essential fatty acid availability in the body. Changes may occur in the liver that limits distribution and availability of fat to the body as an energy source or for other essential functions.
Other: Blood draws
Biological: Oral administration of stable isotope (deuterium)
Procedure: Metabolic rate testing
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||Metabolism of Lipids in Advanced Cancer|
- Rate of hepatic de novo lipogenesis [ Time Frame: 9 months ] [ Designated as safety issue: No ]
- Measures of fat transport and availability [ Time Frame: 9 months ] [ Designated as safety issue: No ]
- Resting metabolic rate & fat oxidation [ Time Frame: 9 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||October 2009|
|Study Completion Date:||October 2011|
|Primary Completion Date:||October 2011 (Final data collection date for primary outcome measure)|
Lung cancer patients who exhibit abnormalities in lipid measures.
Other: Blood draws
Up to 4 blood draws will be required, in the amount of about 10 mL eachBiological: Oral administration of stable isotope (deuterium)
1 mg deuterium-labeled water/kg body water (loading dose), and 0.5 mg/kg body water diluted in 1 L of normal water (maintenance dose) to be consumed over the following 16 hours
Other Name: C/D/N Isotopes, Deuterium Oxide, CAS No: 7789-20-0Procedure: Metabolic rate testing
Metabolic rate testing is a painless, non-invasive test that takes about 1h. A metabolic cart is used, which detects the amount of oxygen and carbon dioxide the body uses. Patients will lie down on a bed for 30 minutes with lights dimmed and soft music to help them relax. After 30 minutes, a canopy will be placed over the patient's head and shoulders for 30 minutes for the analysis of breath samples. This test will be performed only once for this study.
Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves. This research will explore how people with cancer use fat in their body through the use of tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used to trace the production of different fats by the liver. Other methods will determine how much and what types of fat are transported around the body. Body composition will be determined by CT scan and related to fat measures.