Mood and Subthalamic Nucleus (STN) Deep Brain Stimulation (MOST)

This study has been completed.
National Parkinson Foundation
Information provided by (Responsible Party):
University of Florida Identifier:
First received: August 5, 2009
Last updated: November 30, 2011
Last verified: August 2009

The purpose of this research study is to investigate any changes seen in mood or behavior following deep brain stimulation for movement disorders.

Movement Disorders

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Mood and STN Deep Brain Stimulation

Resource links provided by NLM:

Further study details as provided by University of Florida:

Enrollment: 91
Study Start Date: July 2005
Study Completion Date: June 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
Staged Bilateral STN DBS
Simultaneous Bilateral STN DBS


Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Parkinson's patients who undergo STN DBS


Inclusion Criteria:

  • Idiopathic PD diagnosed by a movement disorders neurologist
  • Approved by a movement disorders neurologist as clinically needing a DBS device
  • Absence of significant cognitive dysfunction (Mattis Dementia Rating Scale Score of greater than or equal to 116)
  • MRI without evidence of structural abnormality (stroke, tumor, malformation, etc)
  • No prior neurosurgical intervention

Exclusion Criteria:

  • None
  Contacts and Locations
Please refer to this study by its identifier: NCT00954772

United States, New York
Mt. Sinai School of Medicine
New York, New York, United States, 10029
Sponsors and Collaborators
University of Florida
National Parkinson Foundation
Principal Investigator: Michael S Okun, MD University of Florida
  More Information

No publications provided

Responsible Party: University of Florida Identifier: NCT00954772     History of Changes
Other Study ID Numbers: 00056229
Study First Received: August 5, 2009
Last Updated: November 30, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by University of Florida:
Staged versus Simultaneous Bilateral DBS

Additional relevant MeSH terms:
Movement Disorders
Central Nervous System Diseases
Nervous System Diseases processed this record on April 17, 2014