Study of Blood Samples From Patients With Osteosarcoma

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by National Cancer Institute (NCI).
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00954473
First received: August 6, 2009
Last updated: August 8, 2009
Last verified: August 2009
  Purpose

RATIONALE: Studying the genes found in samples of blood from patients with osteosarcoma may help doctors identify biomarkers related to the disease.

PURPOSE: This research study is looking at blood samples from patients with osteosarcoma.


Condition Intervention
Sarcoma
Genetic: polymorphism analysis
Other: laboratory biomarker analysis

Study Type: Observational
Official Title: Retrospective Study of Genetic Risk Factors for Osteosarcoma

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Gene associations [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Genome-wide associations [ Designated as safety issue: No ]
  • Genomic regions associated with osteosarcoma [ Designated as safety issue: No ]
  • Functional implications of promising genetic variants associated with osteosarcoma [ Designated as safety issue: No ]

Estimated Enrollment: 1000
Study Start Date: January 2009
Detailed Description:

OBJECTIVES:

Primary

  • Conduct a large-scale candidate gene-association study in patients with osteosarcoma using cases from clinical trials COG-P9851 and COG-AOST06B1.

Secondary

  • Conduct a genome-wide association study of osteosarcoma.
  • Fine-map genomic regions associated with osteosarcoma to identify putative functional loci.
  • Investigate the functional implications of promising genetic variants associated with osteosarcoma.

OUTLINE: This is a multicenter study.

Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and haplotypes to examine genetic variation, gene-gene interactions, and the population structure.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Blood samples collected from clinical trials COG-P9851 and COG-AOST06B1

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00954473

Sponsors and Collaborators
Children's Oncology Group
Investigators
Study Chair: Sharon A. Savage, MD National Cancer Institute - EPN
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00954473     History of Changes
Other Study ID Numbers: CDR0000633101, COG-AOST08B1
Study First Received: August 6, 2009
Last Updated: August 8, 2009
Health Authority: United States: Federal Government

Keywords provided by National Cancer Institute (NCI):
localized osteosarcoma
metastatic osteosarcoma
recurrent osteosarcoma

Additional relevant MeSH terms:
Osteosarcoma
Sarcoma
Neoplasms, Bone Tissue
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms

ClinicalTrials.gov processed this record on April 17, 2014