Study of Blood Samples From Patients With Osteosarcoma
Recruitment status was Active, not recruiting
RATIONALE: Studying the genes found in samples of blood from patients with osteosarcoma may help doctors identify biomarkers related to the disease.
PURPOSE: This research study is looking at blood samples from patients with osteosarcoma.
|Official Title:||Retrospective Study of Genetic Risk Factors for Osteosarcoma|
- Gene associations [ Designated as safety issue: No ]
- Genome-wide associations [ Designated as safety issue: No ]
- Genomic regions associated with osteosarcoma [ Designated as safety issue: No ]
- Functional implications of promising genetic variants associated with osteosarcoma [ Designated as safety issue: No ]
|Study Start Date:||January 2009|
- Conduct a large-scale candidate gene-association study in patients with osteosarcoma using cases from clinical trials COG-P9851 and COG-AOST06B1.
- Conduct a genome-wide association study of osteosarcoma.
- Fine-map genomic regions associated with osteosarcoma to identify putative functional loci.
- Investigate the functional implications of promising genetic variants associated with osteosarcoma.
OUTLINE: This is a multicenter study.
Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and haplotypes to examine genetic variation, gene-gene interactions, and the population structure.
|Study Chair:||Sharon A. Savage, MD||National Cancer Institute - EPN|