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Trends in Intellectual Development in Down Syndrome

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2010 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00954382
First received: August 5, 2009
Last updated: March 16, 2010
Last verified: March 2010
History of Changes
  Purpose

Previous foreign studies revealed that the IQ in Down syndrome (DS) declines with age, but not any investigation of domestic data in Taiwan was available. Individuals with DS are characterized by limited verbal development, and in this article, authors look into the diverging verbal-nonverbal abilities in the DS phenotype.


Condition
Down Syndrome

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Trends in Intellectual Development, and Diverging Verbal and Non-verbal Abilities in the Down Syndrome Phenotype

Resource links provided by NLM:

MedlinePlus related topics: Down Syndrome
U.S. FDA Resources

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • IQ [ Time Frame: 2001-2010 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • mental age [ Time Frame: 2001-2010 ] [ Designated as safety issue: No ]

Estimated Enrollment: 60
Study Start Date: May 2009
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
IQ trend
all subjects

Detailed Description:

The present study investigated this by analysis the test results of development /intelligence scales. To compare initial cross-sectional data with longitudinal follow-up, about 12 people with DS were included.

  Eligibility

Ages Eligible for Study:   3 Months to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Down syndrome

Criteria

Inclusion Criteria:

  • Down syndrome with psychological test results

Exclusion Criteria:

  • Comorbidity of severe Autism or visual/auditory impairment
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00954382

Contacts
Contact: Lih-Maan Chang, master +886-2-23123456 ext 67211 lmchang@ntu.edu.tw

Locations
Taiwan
NTUH Recruiting
Taipei, Taiwan, 10041
Contact: Lih-Maan Chang, master     +886-2-23123456 ext 67211     lmchang@ntu.edu.tw    
Principal Investigator: Wuh-Liang Hwu, Ph.D.            
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Wuh-Liang Hwu, Ph.D. NTUH
  More Information

No publications provided

Responsible Party: Hwu Wuh-Liang, Department of Pediatrics and Medical Genetics, NTUH
ClinicalTrials.gov Identifier: NCT00954382     History of Changes
Other Study ID Numbers: 200904037R
Study First Received: August 5, 2009
Last Updated: March 16, 2010
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Down syndrome
IQ
mental age
neuropsychological function

Additional relevant MeSH terms:
Down Syndrome
Mental Retardation
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
 Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on May 23, 2013