The Validity of Forced Expiratory Maneuvers in Ataxia Telangiectasia Studied Longitudinally

The recruitment status of this study is unknown because the information has not been verified recently.

Verified August 2009 by Sheba Medical Center.
Recruitment status was Active, not recruiting

Sponsor:

Information provided by:

Sheba Medical Center

ClinicalTrials.gov Identifier:

NCT00951886

First received: August 2, 2009

Last updated: August 3, 2009

Last verified: August 2009

History of Changes

Purpose

Rationale: Forced spirometry maneuvers are not routinely performed in patients with Ataxia Telangiectasia (A-T), even though they suffer from respiratory illnesses.

Objectives: To study the feasibility and validity of forced spirometry in A-T patients.

Methods: Patients will perform spirometry during clinical visits. Parameters studied will be technical quality, relation to predicted values, age, pulmonary illness, body mass index, mutational status and mutation.

Condition
Ataxia Telangiectasia

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Retrospective
Official Title:	The Validity of Forced Expiratory Maneuvers in Ataxia Teleangiectasia Studied Longitudinally

Resource links provided by NLM:

Genetics Home Reference related topics: ataxia-telangiectasia autosomal recessive cerebellar ataxia type 1 complement factor I deficiency infantile-onset spinocerebellar ataxia Marinesco-Sjögren syndrome spinocerebellar ataxia type 1 spinocerebellar ataxia type 2 spinocerebellar ataxia type 3 spinocerebellar ataxia type 6 VLDLR-associated cerebellar hypoplasia

MedlinePlus related topics: Ataxia Telangiectasia

U.S. FDA Resources

Further study details as provided by Sheba Medical Center:

Primary Outcome Measures:

spirometry measurements [ Time Frame: 3 years ] [ Designated as safety issue: No ]

Enrollment:	28
Study Start Date:	July 2009
Estimated Study Completion Date:	July 2009

Eligibility

Ages Eligible for Study:	3 Years to 20 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients with Ataxia Telangiectasia who are followed and treated in the National A-T center at Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel

Criteria

Inclusion Criteria:

Patients with proven Ataxia Telangiectasia

Exclusion Criteria:

inability to perform spirometry

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00951886

Locations

Israel
Pediatric Pulmonary Unit, The Edmond and Lily Safra Children's Hospital Chaim Sheba Medical Center, Tel HaShomer
Ramat-Gan, Israel, 52621

Sponsors and Collaborators

Sheba Medical Center

More Information

No publications provided

Responsible Party:	Sheba medical Center, Ori Efrati, MD, Principal Investigator, Sheba medical Center
ClinicalTrials.gov Identifier:	NCT00951886 History of Changes
Other Study ID Numbers:	SHEBA-08-5418-OE-CTIL
Study First Received:	August 2, 2009
Last Updated:	August 3, 2009
Health Authority:	Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Sheba Medical Center:

Ataxia Teleangiectasia
Spirometry
Respiratory rare diseases

Additional relevant MeSH terms:

Ataxia Telangiectasia
Ataxia
Telangiectasis
Dyskinesias
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Spinocerebellar Ataxias
Cerebellar Ataxia
Cerebellar Diseases

Brain Diseases
Central Nervous System Diseases
Neurocutaneous Syndromes
Vascular Diseases
Cardiovascular Diseases
Genetic Diseases, Inborn
DNA Repair-Deficiency Disorders
Metabolic Diseases
Immunologic Deficiency Syndromes
Immune System Diseases

ClinicalTrials.gov processed this record on May 19, 2013

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