Cassia Cinnamon for Glucose Uptake in Young Women - Full Text View

Purpose

The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood glucose, serum insulin and insulin sensitivity following an oral glucose tolerance test 3 hours after administration of each intervention.

Condition	Intervention
Insulin Resistance Impaired Glucose Tolerance Prediabetes	Dietary Supplement: Cassia cinnamon Procedure: 50 minutes exercise Dietary Supplement: Cellulose Powder

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Supportive Care
Official Title:	Cassia Cinnamon and Acute Endurance Exercise for the Enhancement of Glucose Uptake in Healthy Young Women

Resource links provided by NLM:

MedlinePlus related topics: Blood Sugar Diabetes Medicines Exercise and Physical Fitness Pre-diabetes

Drug Information available for: Cellulose, microcrystalline Dextrose

U.S. FDA Resources

Further study details as provided by Baylor University:

Primary Outcome Measures:

Blood Glucose [ Time Frame: Baseline, 0, 30, 60, 90 and 120 minutes following OGTT ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Serum Insulin [ Time Frame: Baseline, 0, 30, 60, 90 and 120 minutes following OGTT ] [ Designated as safety issue: No ]

Enrollment:	10
Study Start Date:	February 2008
Study Completion Date:	May 2009
Primary Completion Date:	May 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: 5g Cassia cinnamon Experimental treatment group	Dietary Supplement: Cassia cinnamon 5g encapsulated ground bark administered once in experimental session Other Name: Brand: Nature's Bounty
Active Comparator: 50 minutes endurnace exercise Endurance exercise treatment known to influence blood glucose	Procedure: 50 minutes exercise 50 minutes treadmill endurance exercise at 70% of the heart rate reserve (correlated to VO2max)
Placebo Comparator: 5g Cellulose Placebo equivalent in weight and appearance to experimental treatment	Dietary Supplement: Cellulose Powder 5g encapsulated powder administered during placebo experimental session

Eligibility

Ages Eligible for Study:	18 Years to 30 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Sedentary
BMI: 27-45
DXA body fat % greater than 30%
18-30 years of age
Healthy
From the Baylor University campus and surrounding community
Regular sleep habits

Exclusion Criteria:

Not regular users of any species of cinnamon
Not diagnosed with any metabolic disorder or chronic medical condition
Not taking prescription medications for 2 months before the study
Not taking ergogenic aids for 2 months before the study
Not taking oral contraceptives for 2 months before the study
No IUD placed for 2 months before the study

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00951639

Locations

United States, Texas
Baylor University Department of Health, Human Performance, and Recreation
Waco, Texas, United States, 76798

Sponsors and Collaborators

Baylor University

Investigators

Study Chair:	Darryn S Willoughby, Ph.D.	Baylor University
Principal Investigator:	Jean L Gutierrez, Ph.D.	Baylor University

More Information

Publications:

Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007 Jun;85(6):1552-6.

Hlebowicz J, Hlebowicz A, Lindstedt S, Björgell O, Höglund P, Holst JJ, Darwiche G, Almér LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009 Mar;89(3):815-21. Epub 2009 Jan 21.

Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009 Apr;105(6):969-76. Epub 2009 Jan 22.

Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007 Nov;9(6):895-901.

Responsible Party:	Darryn Willoughby, Baylor University Department of Health, Human Performance, and Recreation
ClinicalTrials.gov Identifier:	NCT00951639 History of Changes
Other Study ID Numbers:	BaylorU_Cassia_Women
Study First Received:	August 3, 2009
Last Updated:	August 3, 2009
Health Authority:	United States: Institutional Review Board

Keywords provided by Baylor University:

Cassia
Cinnamon
Blood Glucose
Endurance exercise

Acute exercise
Overweight
Obesity
Women

Additional relevant MeSH terms:

Insulin Resistance
Glucose Intolerance
Prediabetic State
Hyperinsulinism
Glucose Metabolism Disorders

Metabolic Diseases
Hyperglycemia
Diabetes Mellitus
Endocrine System Diseases

ClinicalTrials.gov processed this record on May 16, 2013