The Effect of Byetta and Symlin on Post-meal Meal Blood Sugar Levels in Children With Type 2 Diabetes (T2DM)
Recruitment status was Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The purpose of this study is to see if giving study drugs before a meal may lower blood sugars after the meal. An improvement in blood sugar control may prevent long-term problems of diabetes.
| Condition | Intervention | Phase |
|---|---|---|
|
Type 2 Diabetes |
Drug: Byetta (exenatide) Drug: Symlin (pramlintide) |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Pharmacokinetics/Dynamics Study Intervention Model: Single Group Assignment Masking: Single Blind (Subject) Primary Purpose: Treatment |
| Official Title: | The Effect of the Glucagon Suppressors Pramlintide and Exenatide on Postprandial Glucose Metabolism in Children With Type 2 Diabetes Mellitus |
- Glucose [ Time Frame: 4 hours ] [ Designated as safety issue: No ]
- glucagon [ Time Frame: 4 hrours ] [ Designated as safety issue: No ]
- gastric emptying [ Time Frame: 4 hours ] [ Designated as safety issue: No ]
- pramlintide concentrations [ Time Frame: 4 hours ] [ Designated as safety issue: No ]
- exenatide concentrations [ Time Frame: 4 hours ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 16 |
| Study Start Date: | July 2009 |
| Estimated Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: exenatide
exenatide one dose
|
Drug: Byetta (exenatide)
exenatide 5 mcg subcutaneously
Other Name: Byetta
|
|
Active Comparator: pramlintide
pramlintide one dose
|
Drug: Symlin (pramlintide)
pramlintide 60 mcg subcutaneously
Other Name: Symlin
|
Detailed Description:
A large study in people with type 2 diabetes (T2DM) showed that lowering blood sugars stopped or delayed the occurrence of health problems. As a result of the study, treatment should try to control blood sugars as near to normal as safely possible.
In people without diabetes, the "after meal" blood sugar level is very carefully controlled by several hormones. Insulin (the hormone that lowers blood sugar) and glucagon (hormone that raises blood sugar) play a key role in keeping this careful balance. Also, we now know of 2 new substances made by the body called amylin and GLP-1 that also help with this careful balance. Amylin is made in the pancreas. GLP-1 is made in the gut. We know that both amylin and GLP-1 are abnormal in people with diabetes.
There are two medicines that may help to control after meal blood sugars from going too high. The medicines are called Symlin (pramlintide) and Byetta (exenatide). Symlin works like amylin. Byetta works like GLP-1. Both medications are very similar in the ways that they work to control blood sugars.
Both medicines help to keep glucagon lower after a meal. They both also help the stomach to digest food more slowly so the blood sugar does not go up too fast after eating. They also help to control how much hunger a person may have before meals. This may help a person to eat less and possibly lose weight. Byetta also seems to help islet cells (cells that make insulin) make more insulin.
Byetta and Symlin are FDA approved for use in adults with T2DM. We want to study these drugs in children with T2DM.
Eligibility| Ages Eligible for Study: | 12 Years to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Children with Type 2 Diabetes,
- Between the ages of 12-21 years,
- Tanner stage 4-5 for pubertal development,
- Menstruating females must have a negative urine pregnancy test for inclusion,
- Must have T2DM for at least 6 months,
- History of negative anti-glutamic acid decarboxylase (GAD) -65 and anti-islet cell antibodies,
- HbA1c < 8.5% and on a stable dose of an oral hypoglycemic agent (with or without insulin) over the last 2 months, or well controlled on diet.
Exclusion Criteria:
- A history of a chronic disease other than diabetes (leukemia, asthma, inflammatory bowel disease, cystic fibrosis, juvenile rheumatoid arthritis, dyslipidemia, cholelithiasis etc),
- BMI> 40 kg/m2,
- Weight of < 60 kg,
- Female with menstrual irregularities,
- Allergy to local anesthetics (ELAMAX Cream, Ethyl Chloride),
- Evidence or history of chemical abuse,
- Anemia (age specific normal range for hemoglobin will be used),
- Elevated liver enzymes (defined as more than 3 times the upper limit of the normal range for age),
- Elevated BUN or creatinine (defined as more than 3 times the upper limit of the normal range for age),
- Use of medications that may increase the blood sugars and admission to the hospital for diabetes related problems over the last 6 months.
Contacts and Locations| Contact: Kathy Shippy, RN | 832-822-3768 | kshippy@bcm.edu |
| United States, Texas | |
| Baylor College of Medicine | Recruiting |
| Houston, Texas, United States, 77030 | |
| Sub-Investigator: MOREY W HAYMOND, MD | |
| Sub-Investigator: AGNETA L SUNEHAG, MD | |
| Sub-Investigator: RUBINA A HEPTULLA, MD | |
| Sub-Investigator: SIRIPOOM V MCKAY, MD | |
| Principal Investigator: | LUISA M RODRIGUEZ, MD | Baylor College of Medicine |
More Information
No publications provided
| Responsible Party: | Luisa M Rodriguez, MD, Baylor College of Medicine |
| ClinicalTrials.gov Identifier: | NCT00950677 History of Changes |
| Other Study ID Numbers: | H-22439 |
| Study First Received: | July 30, 2009 |
| Last Updated: | December 9, 2010 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Baylor College of Medicine:
|
Diabetes pramlintide Symlin exenatide |
byetta glucagon gastric emptying |
Additional relevant MeSH terms:
|
Diabetes Mellitus Diabetes Mellitus, Type 2 Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases Exenatide Pramlintide Islet Amyloid Polypeptide |
Hypoglycemic Agents Physiological Effects of Drugs Pharmacologic Actions Appetite Depressants Anti-Obesity Agents Central Nervous System Agents Therapeutic Uses |
ClinicalTrials.gov processed this record on May 23, 2013