The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression
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Purpose
The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.
| Condition | Intervention |
|---|---|
|
Hypertension |
Other: Kiwi fruits Other: Apple |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression in Mildly Hypertensive Subjects |
- Blood pressure [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
- Endothelial function [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
| Enrollment: | 118 |
| Study Start Date: | August 2009 |
| Study Completion Date: | December 2010 |
| Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Active Comparator: Kiwi fruits |
Other: Kiwi fruits
Daily intake of 3 kiwi fruits for 8 weeks
Other Name: Kiwi fruits
|
| Placebo Comparator: Apple |
Other: Apple
Daily intake of 1 apple (equivalent in energy) for 8 weeks
Other Name: Apple
|
Detailed Description:
An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.
Eligibility| Ages Eligible for Study: | 35 Years to 69 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Systolic blood pressure 130-159 mmHg
- Diastolic blood pressure 85-99 mmHg
- Body mass index <35 kg/m2
Exclusion Criteria:
- Systolic blood pressure >160 mmHg or <129 mmHg
- Diastolic blood pressure >100 mmHg or <84 mmHg
- Current use or need for blood pressure lowering medication
- Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.
Contacts and Locations| Norway | |
| Department of Preventive Cardiology | |
| Oslo, Norway, 0407 | |
| Oslo University Hospital | |
| Oslo, Norway, 0407 | |
| Principal Investigator: | Serena Tonstad, Professor | Preventive Cardiology, Oslo University Hospital |
More Information
No publications provided
| Responsible Party: | Professor Serena Tonstad, Oslo University Hospital, Preventive Cardiology |
| ClinicalTrials.gov Identifier: | NCT00948363 History of Changes |
| Other Study ID Numbers: | 1335 |
| Study First Received: | July 27, 2009 |
| Last Updated: | April 18, 2011 |
| Health Authority: | Norway: Ethics Committee Norway: Norwegian Institute of Public Health |
Keywords provided by Oslo University Hospital:
|
Kiwi fruits Blood pressure Endothelial function Antioxidant capacity |
Additional relevant MeSH terms:
|
Hypertension Vascular Diseases Cardiovascular Diseases Antioxidants |
Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Protective Agents Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on May 16, 2013