The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression

This study has been completed.
Sponsor:
Collaborator:
University of Oslo
Information provided by:
Oslo University Hospital
ClinicalTrials.gov Identifier:
NCT00948363
First received: July 27, 2009
Last updated: April 18, 2011
Last verified: April 2011
  Purpose

The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.


Condition Intervention
Hypertension
Other: Kiwi fruits
Other: Apple

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression in Mildly Hypertensive Subjects

Resource links provided by NLM:


Further study details as provided by Oslo University Hospital:

Primary Outcome Measures:
  • Blood pressure [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Endothelial function [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]

Enrollment: 118
Study Start Date: August 2009
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Kiwi fruits Other: Kiwi fruits
Daily intake of 3 kiwi fruits for 8 weeks
Other Name: Kiwi fruits
Placebo Comparator: Apple Other: Apple
Daily intake of 1 apple (equivalent in energy) for 8 weeks
Other Name: Apple

Detailed Description:

An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.

  Eligibility

Ages Eligible for Study:   35 Years to 69 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Systolic blood pressure 130-159 mmHg
  • Diastolic blood pressure 85-99 mmHg
  • Body mass index <35 kg/m2

Exclusion Criteria:

  • Systolic blood pressure >160 mmHg or <129 mmHg
  • Diastolic blood pressure >100 mmHg or <84 mmHg
  • Current use or need for blood pressure lowering medication
  • Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00948363

Locations
Norway
Department of Preventive Cardiology
Oslo, Norway, 0407
Oslo University Hospital
Oslo, Norway, 0407
Sponsors and Collaborators
Oslo University Hospital
University of Oslo
Investigators
Principal Investigator: Serena Tonstad, Professor Preventive Cardiology, Oslo University Hospital
  More Information

No publications provided

Responsible Party: Professor Serena Tonstad, Oslo University Hospital, Preventive Cardiology
ClinicalTrials.gov Identifier: NCT00948363     History of Changes
Other Study ID Numbers: 1335
Study First Received: July 27, 2009
Last Updated: April 18, 2011
Health Authority: Norway: Ethics Committee
Norway: Norwegian Institute of Public Health

Keywords provided by Oslo University Hospital:
Kiwi fruits
Blood pressure
Endothelial function
Antioxidant capacity

Additional relevant MeSH terms:
Hypertension
Vascular Diseases
Cardiovascular Diseases
Antioxidants
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protective Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on April 17, 2014