Effect of Pimecrolimus Cream on Cathelicidin Levels in Subjects With Eczema
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Purpose
The purpose of this study is to determine the effect of topical pimecrolimus on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with eczema. It is hypothesized that pimecrolimus applied topically will repair the body's immune system in patients with eczema by increasing antimicrobial peptides.
| Condition | Intervention |
|---|---|
|
Atopic Dermatitis |
Drug: Pimecrolimus Other: Vehicle cream |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Treatment |
| Official Title: | A Three-week, Double-blind, Randomized Study to Evaluate the Effect of Pimecrolimus Cream 1% on Cathelicidin Expression in the Skin of Subjects With Atopic Dermatitis |
- To determine the effect of pimecrolimus on the antimicrobial peptide cathelicidin in adult skin from patients with AD [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
- To determine the effect of pimecrolimus on HBD-2, HBD-3, IL-13, and BCL-3 in adult skin from patients with AD [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
| Enrollment: | 40 |
| Study Start Date: | October 2009 |
| Study Completion Date: | May 2011 |
| Primary Completion Date: | February 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Active Comparator: Pimecrolimus |
Drug: Pimecrolimus
20 AD patients will be given pimecrolimus 1% to apply twice daily for up to three weeks on each lesional site predetermined at baseline. AD severity will be evaluated by the Investigator Global Assessment of Disease Activity (IGA). The IGA scale is 0=clear, 1=almost clear, 2=mild, 3=moderate, 4=severe disease. The patient's AD will be evaluated on Visit 1 (Day -14 to 1), Visit 2 (Day 1), and Visit 3 (Week 21). Lesional target site and non-lesional site will be determined at Visit 1. Two 2 mm biopsies will be obtained from a target AD lesion and non-lesional sites at Visit 2, and Visit 3 (four biopsies each visit). Other Names:
|
| Sham Comparator: Vehicle cream |
Other: Vehicle cream
20 AD patients will be treated with vehicle cream twice daily for up to 3 weeks on each lesional site predetermined at baseline. AD severity will be evaluated by the Investigator Global Assessment of Disease Activity (IGA). The IGA scale is 0=clear, 1=almost clear, 2=mild, 3=moderate, 4=severe disease9. The patient's AD will be evaluated on Visit 1 (Day -14 to 1), Visit 2 (Day 1), and Visit 3 (Week 21). Lesional target site and non-lesional site will be determined at Visit 1. Two 2 mm biopsies will be obtained from a target AD lesion and non-lesional sites at Visit 2, and Visit 3 (four biopsies each visit). |
Detailed Description:
Patients with atopic dermatitis (AD) have higher rates of skin infections from viruses and bacteria. They also have an impaired innate immune system. Antimicrobial peptides are a component of the innate immune system which are decreased in atopics. In vitro, pimecrolimus has demonstrated its ability to increase antimicrobial peptides. This study will examine the ability of pimecrolimus to increase antimicrobial peptides in vivo in AD patients. Thus, the study will yield a better understanding of the role of pimecrolimus in regulating the immune system in atopics.
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Age 18-70 years
- Target lesion IGA ≥2
- Target IGA=0 (for non-lesional site)
- Male or female of any race and ethnicity
- Chronic AD for more than one year duration
- Subject of child-bearing potential must be willing to practice effective birth control during the study
- Subject agrees to comply with study requirements and attend all required visits.
Exclusion Criteria:
- Patients ≥ 18 years of age with only AD of the face
- Women of childbearing potential not using the contraception method(s) specified in this study (abstinence, IUD, diaphragm, oral contraceptives)
- Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study
- Hypersensitivity to pimecrolimus cream or any excipient of the cream
- Subject has a skin disorder in addition to dermatitis in the areas to be treated
- Subject has Netherton's syndrome or other genodermatoses that result in a defective epidermal barrier
- Pregnant or nursing females
- Immunocompromised patient (e.g., lymphoma, HIV/AIDS, Wiskott-Aldrich Syndrome), or with a history of active or malignant disease (excluding non-melanoma skin cancer)
- History of psychiatric disease or history of alcohol or drug abuse that would interfere with the ability to comply with the study protocol
- Patients known to be non-compliant with a medication regimen
- Subjects with significant concurrent medical condition(s) at screening that in the view of the investigator prohibits participation in the study (e.g., severe concurrent allergic disease, condition associated with malignancy, and condition associated with immunosuppression)
- Active viral or fungal skin infections at the target areas
- Previous participation in this study
- Ongoing participation in another investigational trial
- Use of any oral or topical antibiotic during the study and up to one week prior to entering the study
- Use of any local therapy for AD less than one week prior to screening
- Use of any systemic immunosuppressive therapy for AD less than four weeks prior to screening.
Contacts and Locations| United States, California | |
| University of California, San Diego Thornton Hospital | |
| La Jolla, California, United States, 92037 | |
| Principal Investigator: | Richard Gallo, MD, PhD | University of California, San Diego |
More Information
No publications provided
| Responsible Party: | Alvin Coda MD, Research Fellow |
| ClinicalTrials.gov Identifier: | NCT00946478 History of Changes |
| Other Study ID Numbers: | UCSDMED |
| Study First Received: | July 24, 2009 |
| Last Updated: | July 19, 2011 |
| Health Authority: | United States: Food and Drug Administration |
Keywords provided by University of California, San Diego:
|
atopic dermatitis elidel pimecrolimus CASM981 |
immunity cathelicidin antimicrobial peptide eczema |
Additional relevant MeSH terms:
|
Dermatitis Dermatitis, Atopic Skin Diseases Skin Diseases, Genetic Genetic Diseases, Inborn Skin Diseases, Eczematous Hypersensitivity, Immediate Hypersensitivity Immune System Diseases Pimecrolimus Tacrolimus Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic |
Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Pharmacologic Actions Anti-Inflammatory Agents Therapeutic Uses Antirheumatic Agents Dermatologic Agents Immunosuppressive Agents Immunologic Factors Central Nervous System Agents |
ClinicalTrials.gov processed this record on May 21, 2013