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Trial record 20 of 193 for:    nasopharyngeal cancer | "Nasopharyngeal Neoplasms"
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A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2009 by National University Hospital, Singapore.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National University Hospital, Singapore
ClinicalTrials.gov Identifier:
NCT00943891
First received: July 20, 2009
Last updated: September 16, 2009
Last verified: July 2009
History of Changes
  Purpose
  1. To determine the association between LVD and clinico-pathologic variables in archived colorectal cancer and Nasopharyngeal carcinoma specimens
  2. To determine the association between VEGF-C,-D expression with COX-2 expression and clinico-pathologic variables in colorectal cancer and Nasopharyngeal carcinoma
  3. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma Lymphangiogenesis and factors modulating lymphangiogenesis are associated with clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer. Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of Pathology. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma, the investigators intend to analyze archived specimens collected in a previously conducted study. Colorectal tumor and nodal specimens and Nasopharyngeal carcinoma primary will be examined for MVD, LVD and growth factor expression using established haematoxylin and eosin and immunohistochemical techniques. Quantification of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological variables using standardised methods.

Condition Intervention
Colorectal Cancer
Nasopharyngeal Cancer
 Procedure: Tumor biopsies

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Cross-Sectional
Official Title: A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National University Hospital, Singapore:

Biospecimen Retention:   Samples With DNA

CRC and NPC tumor specimens will be obtained.


Estimated Enrollment: 500
Study Start Date: July 2008
Groups/Cohorts Assigned Interventions
Tumor biopsies Procedure: Tumor biopsies

  Eligibility

Ages Eligible for Study:   21 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Colorectal and nasopharyngeal cancer.

Criteria

Inclusion Criteria:

  • Male and female patients are eligible
  • Patients 21 years or older

Exclusion Criteria:

  • None
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00943891

Contacts
Contact: Ross Andrew Soo, MBBS 65 6772 4624 Ross_Soo@nuhs.edu.sg

Locations
Singapore
National University Hospital Recruiting
Singapore, Singapore, 119074
Contact: Ross Andrew Soo, MBBS     65 6772 4624     Ross_Soo@nuhs.edu.sg    
Principal Investigator: Ross Andrew Soo, MBBS            
Sponsors and Collaborators
National University Hospital, Singapore
Investigators
Principal Investigator: Ross Andrew Soo, MBBS National University Hospital, Singapore
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00943891     History of Changes
Other Study ID Numbers: MC01/09/08
Study First Received: July 20, 2009
Last Updated: September 16, 2009
Health Authority: Singapore: Domain Specific Review Boards

Additional relevant MeSH terms:
Colorectal Neoplasms
Nasopharyngeal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Pharyngeal Neoplasms
Otorhinolaryngologic Neoplasms
Head and Neck Neoplasms
 Nasopharyngeal Diseases
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
Pharyngeal Diseases
Stomatognathic Diseases
Otorhinolaryngologic Diseases

ClinicalTrials.gov processed this record on May 23, 2013