Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Medical University of Graz
ClinicalTrials.gov Identifier:
NCT00942786
First received: July 18, 2009
Last updated: November 20, 2013
Last verified: November 2013
  Purpose

The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.


Condition
3 Years Cardiac Morbidity and Mortality

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Study to Evaluate the Predictive Value of Brain Natriuretic Peptides for Adverse Long-term Cardiac Outcome

Further study details as provided by Medical University of Graz:

Primary Outcome Measures:
  • Major adverse cardiac event [ Time Frame: in-hospital and during 3 years follow-up ] [ Designated as safety issue: Yes ]

Biospecimen Retention:   Samples Without DNA

one vial of serum per patient is retained


Enrollment: 302
Study Start Date: February 2008
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
No treatment
Consecutive patients undergoing emergency surgery

Detailed Description:

The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Consecutive patients undergoing emergency non-cardiac surgery

Criteria

Inclusion criteria:

  • Emergency surgery:

    1. Vascular
    2. Intra-abdominal
    3. Orthopedic

      Exclusion Criteria:

  • Patients unable to provide informed consent
  • Thoracic surgery
  • Trauma surgery
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00942786

Locations
Austria
Department of Anesthesia and Intensive Care Medicine
Graz, Austria, 8036
Sponsors and Collaborators
Medical University of Graz
Investigators
Principal Investigator: Elisabeth Mahla, M.D. Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz
  More Information

No publications provided

Responsible Party: Medical University of Graz
ClinicalTrials.gov Identifier: NCT00942786     History of Changes
Other Study ID Numbers: 19-077 ex 07/08
Study First Received: July 18, 2009
Last Updated: November 20, 2013
Health Authority: Austria: Ethikkommission

Keywords provided by Medical University of Graz:
natriuretic peptides
emergency non-cardiac surgery

Additional relevant MeSH terms:
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs
Pharmacologic Actions
Cardiovascular Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on April 14, 2014