Early Endoscopic Indicators for OACs After Lung Transplantation: Development of a Novel Mucosal Healing Score
Airway complications are a significant cause of morbidity after lung transplantation (LTx). Bronchoscopic evaluation may help to identify risk factors for requiring interventions later.
Airway Complication Which Require Any Intervention
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Early Indicators for Obstructive Airway Complications After Lung|
- Primary endpoint of this study was any obstructive airway complication (AC) which required desobliterative intervention. [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
- secondary endpoint included anastomosis-related death. [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2007|
|Study Completion Date:||August 2009|
|Primary Completion Date:||June 2009 (Final data collection date for primary outcome measure)|
patients with OAC, Score finding
patients without OAC, Score finding
The investigators evaluated lung transplant recipients prospectively. Adult patients surviving 90 day after LTx will be included. The investigators propose a classification of airway healing based on the endoscopic bronchial appearances at days 7, 14, 21, 90, 180 and 365 after LTx. A score system including mucosal healing, full tissue necrosis (=dehiscence), lose sutures, fibrin plugs, polyps and malacia will be developed (max. score 8 points/date). Endoscopic findings will be correlated with the development of obstructive airway complications (OAC, requiring >1 intervention). Afterwards the new score system will be applied prospectively in the patients.