Very Low Dose Caudal Morphine for Postoperative Pain Management
Recruitment status was Active, not recruiting
This is a chart review. The aim of this study is to investigate the effectiveness and side effects of very low dose morphine administered caudally to children that went to surgical procedures that used caudal anesthesia. The study compares caudal block with Bupivacaine (1 ml kg_1 of bupivacaine 0.25% and saline 0.02 ml kg_10) with very low dose morphine (a mix of 1 ml kg_-1 of ropivacaine 0.2% and preservative-free morphine: 10 µg kg-1).
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||The Use of Very Low Dose Caudal Morphine for Postoperative Pain Management in Out Patients|
- The study's primary research question, which relates to between-group differences is duration of analgesia. [ Time Frame: 1 year 5 months ] [ Designated as safety issue: Yes ]
- Between-group differences in the proportion of patients clinically significant side effects will be assessed. [ Time Frame: 1 year 5 months ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2010|
|Estimated Study Completion Date:||August 2012|
|Estimated Primary Completion Date:||August 2012 (Final data collection date for primary outcome measure)|
Review of charts of patients that received very low dose morphine administered caudally (M) and plain caudal block with Ropivacaine or Marcaine (B).
Procedure: Caudal block
Chart review of patients that received very low dose morphine administered caudally (M) and plain caudal block with Ropivacaine or Marcaine (B)from October 2008 to October 2009.
Caudal anesthesia is the most common technique of epidural anesthesia in children. Caudal anesthesia is recommended for most surgical procedures of the lower part of the body, including herniorrhaphies; operations on the urinary tract, anus, and rectum; and orthopedic procedures on the pelvic girdle and lower extremities. Many anesthetic agents have been used for caudal anesthesia in pediatric patients, with lidocaine and Bupivacaine being most common. The major problems associated with this technique are the limited duration of analgesia and unwanted motor blockade.
Addition of medications that prolong analgesia after a single shot caudal block has been investigated. Several authors have mentioned a special interest in using an opioid like morphine in caudal block for postoperative analgesia. When low dose morphine is used, the side effects are lower than when higher dose of morphine are used. A larger and definitive study is needed to compare very low dose morphine via caudal administration and caudal block without Opioid with regard to duration of analgesia and frequency of side effects. We plan to conduct a chart review in our center on pediatric patients that went to urological, orthopedic, and general surgery procedures for which caudal block were given and compare the effectiveness and side effects of very low dose morphine and caudal block without Opioid.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00938821
|United States, Oklahoma|
|The University of Oklahoma Health Sciences Center Deparment of Anesthesiology|
|Oklahoma City, Oklahoma, United States, 73104|
|Principal Investigator:||Alberto J. de Armendi, MD, AM, MBA||Oklahoma University Health Sciences Center|