Effects of Vitamin A Supplementation on Intestinal Parasitic Reinfections
Intestinal parasitic infections, malnutrition and iron deficiency anaemia (IDA) are still considered as public health problems in rural Malaysia especially among Orang Asli children. Despite intermittent control programmes, the prevalence of these problems is still high suggesting the need of other control and interventions measures. This randomized double-blind, placebo-controlled trial was carried out among Orang Asli schoolchildren from Sekolah Kebangsaan Betau in Pos Betau, Pahang (200 km northeast Kuala Lumpur) to investigate the effects of vitamin A supplementation on intestinal parasitic reinfections, growth, iron status and educational achievement.
- Vitamin A supplementation has a negative effect on intestinal parasitic reinfections and the worm burden of infections among Orang Asli schoolchildren in Pos Betau, Kuala Lipis, Pahang.
- Vitamin A supplementation has a positive effect on growth (weight and height) among Orang Asli schoolchildren.
- Vitamin A supplementation is effective in improving serum iron status among Orang Asli schoolchildren.
- Vitamin A supplementation has a positive effect on cognitive function and educational achievement among Orang Asli schoolchildren.
Intestinal Parasitic Infections
Drug: vitamin A supplements
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Prevention
|Official Title:||Effects of Vitamin A Supplementation on Intestinal Parasitic Reinfections, Growth, Iron Status and Educational Achievement Among Orang Asli Schoolchildren in Pos Betau, Pahang, Malaysia|
- intestinal parasitic infections [ Time Frame: 6 months ] [ Designated as safety issue: No ]
- growth , iron status & educational achievement [ Time Frame: 6 months ] [ Designated as safety issue: No ]
|Study Start Date:||May 2007|
|Study Completion Date:||August 2008|
|Primary Completion Date:||August 2008 (Final data collection date for primary outcome measure)|
Placebo Comparator: placebo
125 schoolchildren were allocated randomly to receive placebo
125 children received placebo capsules
Other Name: Group A
Active Comparator: vitamin A supplement
125 children received vitamin A supplements capsules (200 000 IU)
Drug: vitamin A supplements
gelatinous and reddish opaque capsules containing 200 000 IU vitamin A
Other Name: Group B
Children from Sekolah Kebangsaan Betau in Pos Betau, Kuala Lipis, Pahang served as the target population for this study.
The selection criteria for study subjects were the following:
- Age 7-12 years (according to birth date in birth certificate).
- Non-menstruating females (age <13)
- No history or evidence of underlying haematological-related diseases such as thalassaemia and ovalocytosis.
- No evidence of concomitant severe and/or chronic illness such as acute respiratory tract infections, mental retardation and neurological deficits.
- Consent of parent to participate in the study.
|National school of Pos Betau|
|Kuala Lipis, Pahang, Malaysia|
|Principal Investigator:||Hesham M Al-Mekhlafi, PhD||University of Malaya|