Cortisol Activity in Patients With Prader-Willi Syndrome and Healthy Controls

This study has been completed.
Information provided by:
Children's Mercy Hospital Kansas City Identifier:
First received: July 2, 2009
Last updated: June 23, 2011
Last verified: June 2011

The purpose of the study is to find out if people with Prader-Willi syndrome have a difference in the protein which changes inactive cortisone to the active stress hormone cortisol.

Prader-Willi Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: 11 Beta Hydroxysteroid Dehydrogenase 1 (11-beta HSD 1) Activity in Patients With Prader-Willi Syndrome and in Healthy Controls

Resource links provided by NLM:

Further study details as provided by Children's Mercy Hospital Kansas City:

Estimated Enrollment: 36
Study Start Date: February 2009
Study Completion Date: August 2010
PWS not receiving Growth Hormone
Control subjects healthy or obese
PWS subjects starting Growth Hormone


Ages Eligible for Study:   6 Months and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Defined population


Inclusion Criteria:

  • Prader-Willi syndrome confirmed by molecular testing, ages 6 months to adult
  • Controls: Age-matched, sex-matched, developmentally normal, BMI-controlled healthy or obese subjects

Exclusion Criteria:

  • PWS subjects without molecular confirmation of the diagnosis
  • Subjects receiving glucocorticoid treatment within 3 months of evaluation
  • Subjects receiving growth hormone within one year prior to analysis
  Contacts and Locations
Please refer to this study by its identifier: NCT00932932

Sponsors and Collaborators
Children's Mercy Hospital Kansas City
Principal Investigator: Wayne Moore, MD Children's Mercy Hospital Kansas City
  More Information

No publications provided

Responsible Party: Jill Jacobson,MD, Children's Mercy Hospitals and Clinics Identifier: NCT00932932     History of Changes
Other Study ID Numbers: 09 01-014
Study First Received: July 2, 2009
Last Updated: June 23, 2011
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Prader-Willi Syndrome
Mental Retardation
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Nutrition Disorders processed this record on April 20, 2014