Vitamin K-absorption From Dairy
Lactic acid bacteria produce a mixture of higher menaquinones, including menaquinone-9 (MK-9) and menaquinone-10 (MK-10). Vitamin K1 (phylloquinone) is normally present in chloroplasts in green vegetables. A new dairy product is developed containing both vitamin K1 and K2-vitamins. However, the extent to which the various forms of vitamin K are absorbed from such a mixture is not known. In this study the absorption profile of phylloquinone and menaquinones from this new dairy product containing several K-vitamins is investigated. This study describes a dietary intervention experiment for one single cocktail containing several K-vitamins as part of a dairy product.
|Study Design:||Endpoint Classification: Bio-availability Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Absorption of Different Forms of Vitamin K From Dairy Products|
- serum vitamin K levels: phylloquinone, menaquinone-7,-8,-9,and -10 [ Time Frame: one single intake ] [ Designated as safety issue: No ]
- distribution of vitamin K-forms over lipoprotein fractions: triglyceride rich lipoprotein (TGRLP), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), high density lipoprotein (HDL) as well as the lipoprotein-free fraction (LPF) [ Time Frame: one single intake ] [ Designated as safety issue: No ]
|Study Start Date:||April 2009|
|Study Completion Date:||November 2009|
|Primary Completion Date:||July 2009 (Final data collection date for primary outcome measure)|
Experimental: vitamin K-rich dairy product
one single intake of a dairy product containing several K-vitamins: phylloquinone, menaquinone-7,8,9-and 10.
Dietary Supplement: vitamin K-rich dairy product
several forms of vitamin K: phylloquinone, menaquinone-7,-8,-9,and -10.
|VitaK BV / University of Maastricht|
|Principal Investigator:||Cees Vermeer, PhD||VitaK / University of Maastricht|