Automating Breast Radiation Therapy (RT)
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Purpose
Breast radiation treatment is planned from a Computed Tomography (CT) scan. This study is designed to investigate a method to reduce the time between the planning of radiation treatment and its actual start by automating the intensity-modulated radiation therapy (IMRT) planning process. The investigators plan to examine data from another scan called Cone Beam Computed Tomography (CBCT). A CBCT scan provides similar information to a conventional CT scan, however the images for CBCT are acquired at the treatment unit (linear accelerator used for treatment). Using these x-ray pictures of patients, the study team consisting of a radiation oncologist, a medical physicist and a radiation therapist will create a custom treatment plan unique to each patient. By doing this, the investigators hope to reduce the amount of time spent waiting for treatment and the number of hospital visits for patients in the future.
| Condition | Intervention |
|---|---|
|
Breast Cancer |
Procedure: Cone Beam CT |
| Study Type: | Interventional |
| Study Design: | Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Automating the Breast Radiation Therapy Process to Improve Efficiency |
- To generate on-line IMRT treatment plans using automated tools based on CBCT images acquired at the treatment unit. [ Time Frame: 3 years ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 160 |
| Study Start Date: | June 2009 |
| Estimated Study Completion Date: | June 2014 |
| Estimated Primary Completion Date: | June 2014 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Experimental: Cone Beam CT |
Procedure: Cone Beam CT
Patients will also have a CBCT scan when they are having their first IMRT treatment.
|
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients with breast cancer who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions.
- Patients with any stage of breast cancer.
- Patients with prior treatment such as surgery or chemotherapy for any type of cancer.
- Able to provide a written informed consent.
- 18 years of age or older.
Exclusion Criteria:
- < 18 years of age.
- Unable to provide informed consent.
- Males.
- Patients who received partial breast radiation and not the standard dose.
- Patients who will not receive 4240 cGy in 16 fractions, 5000 cGy in 25 fractions, or 4000 cGy in 16 fractions.
Contacts and Locations| Contact: Robert Dinniwell, MD | 416 946 4501 ext 4662 | robert.dinniwell@rmp.uhn.on.ca |
| Canada, Ontario | |
| University Health Network, Princess Margaret Hospital | Recruiting |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Contact: Robert Dinniwell, MD 416 946 4501 ext 4662 Robert.Dinniwell@rmp.uhn.on.ca | |
| Principal Investigator: Robert Dinniwell, MD | |
| Principal Investigator: | Robert Dinniwell, MD | University Health Network, Princess Margaret Hospital |
More Information
No publications provided
| Responsible Party: | University Health Network, Toronto |
| ClinicalTrials.gov Identifier: | NCT00923871 History of Changes |
| Other Study ID Numbers: | UHN REB 09-0197-CE |
| Study First Received: | June 16, 2009 |
| Last Updated: | January 3, 2013 |
| Health Authority: | Canada: Ethics Review Committee |
Keywords provided by University Health Network, Toronto:
|
CBCT Breast Cancer |
Additional relevant MeSH terms:
|
Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases |
ClinicalTrials.gov processed this record on May 21, 2013