Progression of Cognitive and Physical Symptoms in Multiple Sclerosis
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Purpose
The purpose of this study is to look at multiple sclerosis patients process of awareness, learning, and judging status over a 3 year time period.
| Condition |
|---|
|
Multiple Sclerosis |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Progression of Cognitive, Affective, and Physical Symptoms in Multiple Sclerosis. |
| Estimated Enrollment: | 100 |
| Study Start Date: | August 2008 |
| Estimated Study Completion Date: | August 2013 |
| Estimated Primary Completion Date: | August 2013 (Final data collection date for primary outcome measure) |
Patients with multiple sclerosis (MS) frequently experience cognitive and emotional difficulties. Theses neuropsychiatric symptoms are known to be associated with reduced quality of life. However, little is known about the evolution of MS patients' neuropsychiatric difficulties and how these neuropsychiatric changes may be related to other MS symptoms. The purpose of the present study is to examine MS patients' cognitive and emotional status over time as part of standard neuropsychological evaluations in a private practice setting. MS patients presenting for neuropsychological evaluation at the MidAmerica Neuroscience Institute will be provided with the option of participating in thorough evaluation of their cognitive and affective MS symptoms. They will then be followed clinically and receive re-evaluation over a period of 3 years on a yearly basis. It is hoped that this study will help us obtain a better understanding of the factors associated with worsening cognition in MS. A greater understanding of the factors associated with cognitive and affective decline in MS help could lead to the early identification and treatment of at-risk patients.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Neurology Care Clinic
Inclusion Criteria:
- Male/female subjects at least 18 years of age with a diagnosis of Clinically Definite Multiple Sclerosis (CDMS) or Clinically Isolated Syndrome (CIS)as confirmed by a neurologist.
- Subjects must be able to give written informed consent and comply with the study protocol. Subjects must also be able to read, write and understand English.
- Are capable of performing the requirements of the neuropsychological test battery.
Exclusion Criteria:
- As judged by the investigator, any clinically significant, unstable or major concomitant disorder or medications.
- In the opinion of the Investigator should not participate in the study.
Contacts and Locations| Principal Investigator: | Hunter T Feaster, PsyD | MidAmerica Neuroscience Institute |
| Principal Investigator: | Jared Bruce, PhD | University of Missouri, Kansas City |
More Information
No publications provided
| Responsible Party: | H. Todd Feaster, PsyD, MidAmerica Neuroscience Institute |
| ClinicalTrials.gov Identifier: | NCT00922831 History of Changes |
| Other Study ID Numbers: | 080514 |
| Study First Received: | June 16, 2009 |
| Last Updated: | June 16, 2009 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by MidAmerica Neuroscience Institute:
|
Cognition, Affective MS symptoms |
Additional relevant MeSH terms:
|
Multiple Sclerosis Sclerosis Demyelinating Autoimmune Diseases, CNS Autoimmune Diseases of the Nervous System Nervous System Diseases |
Demyelinating Diseases Autoimmune Diseases Immune System Diseases Pathologic Processes |
ClinicalTrials.gov processed this record on May 16, 2013