Heliox and Posture in Patients With Asthma
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Purpose
The purpose of this study is to verify that nebulization with bronchodilators associated with heliox gas (helium + oxygen) and the posture of a leaning forward truck is effective in patients with an asthma attack.
| Condition | Intervention |
|---|---|
|
Acute Asthma |
Other: HELIOX Other: OXYGEN Other: HELIOX+POSTURE Other: OXYGEN + POSTURE |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Factorial Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Treatment |
| Official Title: | Heliox and Posture Optimize Action of Nebulization With Bronchodilators for Asthma Attacks. Randomized Trial. |
- Spirometry [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
- Respiratory rate [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
- Peripheral oxygen saturation [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
- Borg scale [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
- Heart rate [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
| Enrollment: | 59 |
| Study Start Date: | June 2008 |
| Study Completion Date: | December 2008 |
| Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: heliox
The patients in this group underwent nebulization with heliox carried by the trunk erect
|
Other: HELIOX
The nebulization was conducted in the same way that heliox + posture group, except the attitude of trunk, where the patients in this group did the Nebulizer with the trunk upright.
Other Names:
|
|
Experimental: heliox+posture
The patients in this group carried out the mist carried by heliox and the trunk tilted forward
|
Other: HELIOX+POSTURE
Patients underwent two carried by heliox nebulization associated with fenoterol (2.5 mg) and ipratropium bromide (0.25 mg). We used three ml of saline solution at 0.9%. For nebulization with heliox or oxygen, was used a system of distribution not invasive, semi-closed in a mask that is non toxic connected to a piece "Y" with a nebulizer in a follow and a bag of tank with a capacity for 2.5 L in the other connected with a valve action. This system was used so that there was a dilution gas. The proportion of 80:20 heliox was used (80% helium: 20% oxygen). To postural change in groups and heliox Oxygen + posture + posture, oriented to the participants to maintain an angle of inclination of the trunk and elbows supported on the thighs, measured from the anterior axillary line and lateral epicondyle of the femur, between 50th and 60th .
Other Names:
|
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Experimental: oxygen+posture
The patients in this group carried out the mist carried by oxygen and the trunk tilted forward
|
Other: OXYGEN + POSTURE
The NEBULIZATION was conducted in the same way that heliox + posture GROUP, however the patients in this group have the Oxygen for Carr A NEBULIZATION
Other Names:
|
|
Active Comparator: oxygen
The patients in this group carried out the mist carried by the oxygen and the trunk upright
|
Other: OXYGEN
The NEBULIZATION was performed the same way as the heliox group, except for torso posture, where the patients in this group with the trunk upright Nebulizer Oxygen for cars have A NEBULIZATION.
Other Names:
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Detailed Description:
When associated with inhaled bronchodilators, the heliox, a mixture of helium and oxygen in obstructive lung diseases with asthma, reduces the turbulence of airflow despite high rates, due to its low density.
Although the first report of the use of heliox in the treatment of asthma dating to 1935, few controlled studies are available clarify the impact of the use of heliox in hospital admission of patients with acute asthma attacks refractory to standard treatment.
The severe airflow obstruction, observed in cases of acute asthma, also leads to lung hyperinflation that favors the increase of respiratory work by increasing the load for the inspiratory muscles by placing them at a mechanical disadvantage.
Various body positions were studied relating them to muscle activity with mechanical disadvantage. These studies suggest that the influence posture acts mainly in the position of the diaphragm, thus, increasing the stress related to other muscles such as the abdominals and the effect of gravity on these.
This study aims to: assess the efficiency of the positioning body associated with nebulization with bronchodilators carried by heliox during acute severe asthma in adults, using as the primary outcomes FEV1, FVC and PEF and secondary outcomes as the Borg scale, inspiratory capacity, RR, HR and SpO2.
Eligibility| Ages Eligible for Study: | 18 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- reversibility of bronchial obstruction after administration of bronchodilator drugs for at least 10% in FEV1
- a clinical diagnosis of acute severe asthma
- a history of asthma over 1 year
- duration of the crisis of current asthma lasting less than seven days
Exclusion Criteria:
- were unable to understand or perform the spirometric maneuver
- smoking (within the last 3 years associated with a higher consumption of 100 cigarettes/year)
- other pulmonary comorbidities
- lower to upper airways
- heart failure
- heart rate greater than 150 bpm
- systolic pressure below 90 mmHg or greater than 150 MHG
- pregnancy
- inability to stay inline with the trunk forward
Contacts and Locations More Information
Additional Information:
Publications:
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Daniella Cunha Brandão, Department of Physiotherapy |
| ClinicalTrials.gov Identifier: | NCT00922350 History of Changes |
| Other Study ID Numbers: | 2525 |
| Study First Received: | June 8, 2009 |
| Last Updated: | June 16, 2009 |
| Health Authority: | Brazil: National Health Surveillance Agency |
Keywords provided by Universidade Federal de Pernambuco:
|
asthma heliox bronchodilators posture |
Additional relevant MeSH terms:
|
Asthma Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases |
Bronchodilator Agents Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Pharmacologic Actions Anti-Asthmatic Agents Respiratory System Agents Therapeutic Uses |
ClinicalTrials.gov processed this record on May 23, 2013