Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

This study is currently recruiting participants.

Verified February 2012 by National Cancer Institute (NCI)

First Received on June 11, 2009. Last Updated on February 5, 2012 History of Changes

Sponsor:	Children's Oncology Group
Collaborator:	National Cancer Institute (NCI)
Information provided by:	National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:	NCT00919750

Purpose

RATIONALE: Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

PURPOSE: The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory.

Condition	Intervention
Brain and Central Nervous System Tumors	Other: biologic sample preservation procedure

Study Type:	Observational
Official Title:	A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens

Resource links provided by NLM:

MedlinePlus related topics: Brain Cancer Cancer Childhood Brain Tumors

U.S. FDA Resources

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:

Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children's Oncology Group institutions [ Designated as safety issue: No ]
Creation of a repository for long-term storage of these specimens [ Designated as safety issue: No ]
Making these specimens available to qualified researchers to understand the biology of pediatric brain tumors [ Designated as safety issue: No ]

Study Start Date:

March 2005

Detailed Description:

OBJECTIVES:

Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children's Oncology Group institutions.
Provide a repository for long-term storage of specimens from these patients.
Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors.

OUTLINE: This is a multicenter study

Brain tumor tissue and blood specimens are collected from patients and banked for future study.

PROJECTED ACCRUAL: An unlimited number of specimens will be collected.

Eligibility

Ages Eligible for Study:	up to 18 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

DISEASE CHARACTERISTICS:

Diagnosis of brain tumor
Previously treated at a Children's Oncology Group (COG) institution
- Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm
Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission

PATIENT CHARACTERISTICS:

Not specified

PRIOR CONCURRENT THERAPY:

Not specified

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00919750

Show 159 Study Locations

Sponsors and Collaborators

Children's Oncology Group

National Cancer Institute (NCI)

Investigators

Study Chair:	Scott Pomeroy, MD	Children's Hospital Boston
Investigator:	Jaclyn A. Biegel, PhD	Children's Hospital of Philadelphia

More Information

Additional Information:

Clinical trial summary from the National Cancer Institute's PDQ® database This link exits the ClinicalTrials.gov site

No publications provided

ClinicalTrials.gov Identifier:	NCT00919750 History of Changes
Obsolete Identifiers:	NCT00228748
Other Study ID Numbers:	CDR0000352347, COG-ACNS02B3
Study First Received:	June 11, 2009
Last Updated:	February 5, 2012
Health Authority:	Unspecified

Keywords provided by National Cancer Institute (NCI):

childhood grade I meningioma
childhood grade II meningioma
childhood grade III meningioma
recurrent childhood cerebellar astrocytoma
recurrent childhood cerebral astrocytoma
recurrent childhood ependymoma
recurrent childhood medulloblastoma
recurrent childhood supratentorial primitive neuroectodermal tumor
recurrent childhood visual pathway and hypothalamic glioma
recurrent childhood visual pathway glioma

childhood central nervous system germ cell tumor
newly diagnosed childhood ependymoma
childhood choroid plexus tumor
childhood craniopharyngioma
childhood infratentorial ependymoma
childhood oligodendroglioma
childhood supratentorial ependymoma
childhood high-grade cerebral astrocytoma
childhood low-grade cerebral astrocytoma
childhood atypical teratoid/rhabdoid tumor

Additional relevant MeSH terms:

Brain Neoplasms
Nervous System Neoplasms
Central Nervous System Neoplasms
Neoplasms by Site

Neoplasms
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on February 09, 2012