Visual Exploration and Attention: Studies in Patients With Schizophrenia and Autism Spectrum Disorders

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2012 by University Hospital, Strasbourg, France
Sponsor:
Information provided by (Responsible Party):
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT00914030
First received: June 2, 2009
Last updated: June 28, 2012
Last verified: June 2012
  Purpose

The aim of the protocol is to better understand the impairments in visual processing, as such impairments may induce social interaction difficulties in subjects with autism spectrum disorders (adults and children) and schizophrenia, like face exploration.The same protocol will be used for the three populations, each population being compared with matched controls. The explorations are designed to test two different hypotheses regarding the mechanisms of the visual perception difficulties of the two populations. Even though difficulties to extract the global form of objects have been described in both subjects with autism and schizophrenia, we will test two different hypotheses for the two populations. We will test the hypothesis that subjects with autism display an advantage for the processing of local information arising at an early level of processing, whereas disorders observed in patients with schizophrenia originate from attention disorders. The protocol includes three consecutive studies, each one being applied in each of the three populations.


Condition Intervention
Autism Spectrum Disorders
Schizophrenia
Other: Neuropsychological evaluation

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Visual Exploration and Attention : Studies in Patients With Schizophrenia and Autism Spectrum Disorders

Resource links provided by NLM:


Further study details as provided by University Hospital, Strasbourg, France:

Estimated Enrollment: 140
Study Start Date: June 2009
Estimated Study Completion Date: August 2014
Estimated Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
A1
Patients with schizophrenia
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
A2
Control subjects matched individually with patients with schizophrenia
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
B1
Adult subjects with autism
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
B2
Control subjects matched individually with adult subjects with autism
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
C1
Children with autism
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
C2
Control subjects matched individually with children with autism
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).

  Eligibility

Ages Eligible for Study:   7 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Psychiatry clinic in Strasbourg and Brumath. Pedopsychiatry Clinic in Strasbourg. Residents of Strasbourg and Brumath

Criteria

Inclusion Criteria:

  • IQ above 70, as evaluated with the WAIS III in adults and with the WISC in children
  • signed consent
  • DSM IV criteria in case of autism spectrum disorders or schizophrenia

Exclusion Criteria:

  • grave or non stabilized somatic pathology
  • pathology affecting the central nervous system; other than the studied pathologies
  • intake of psychotropic drug, except for patients
  • invalidating sensory processes
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00914030

Contacts
Contact: GIERSCH Anne, MD giersch@unistra.fr

Locations
France
Pôle départemental du Centre de Ressources Autisme pour adultes (67) - Etablissement public de santé Alsace-Nord (site de Brumath) Recruiting
Brumath, France, 67170
Contact: HOCHNER Arielle, MD       arielle.hochner@ch-epsan.fr   
Principal Investigator: HOCHNER Arielle, MD         
Sub-Investigator: WEINER Luisa, MD         
Centre de Ressources Autisme Pôle adultes (68) - Espace Autisme 68 Recruiting
Colmar, France, 68000
Contact: MURAD Ayman, MD       murad@ch-rouffach.fr   
Principal Investigator: MURAD Ayman, MD         
Clinique Lautréamont Recruiting
Loos, France, 59120
Contact: GONIN Olivier, MD       Olivier.gonin4@wanadoo.fr   
Principal Investigator: GONIN Olivier, MD         
INSERM U666 ; Pôle de Psychiatrie - Service de Psychiatrie Adulte- HUS Recruiting
Strasbourg, France, 67091
Contact: GIERSCH Anne, MD       giersch@unistra.fr   
Principal Investigator: GIERSCH Anne, MD         
Pôle régional du Centre de Ressources Autisme pour enfants et adolescents - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - Pôle de Psychiatrie - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - HUS Recruiting
Strasbourg, France, 67000
Contact: GRAS-VINCENDON Agnès, MD       agnes.gras@chru-strasbourg.fr   
Principal Investigator: GRAS-VINCENDON Agnès, MD         
Sub-Investigator: CHABAUX-DELARAI Catherine, MD         
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
Principal Investigator: Anne GIERSCH Institut National de la Santé Et de la Recherche Médicale, France
  More Information

No publications provided

Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT00914030     History of Changes
Other Study ID Numbers: 4371 (2008-A01459-46)
Study First Received: June 2, 2009
Last Updated: June 28, 2012
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by University Hospital, Strasbourg, France:
Visual perception
Local/global processing
Attention
Visual priming
Collinearity
Grouping

Additional relevant MeSH terms:
Autistic Disorder
Schizophrenia
Child Development Disorders, Pervasive
Mental Disorders Diagnosed in Childhood
Mental Disorders
Schizophrenia and Disorders with Psychotic Features

ClinicalTrials.gov processed this record on July 29, 2014