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Time-Dependent Mobilization of Circulating Progenitor Cells During Strenuous Exercise in Healthy Individuals

This study has been completed.
Sponsor:
Collaborators:
University of Jena
Dep. of sports medicine
Information provided by:
University of Leipzig
ClinicalTrials.gov Identifier:
NCT00900107
First received: May 1, 2009
Last updated: May 11, 2009
Last verified: May 2009
History of Changes
  Purpose

Only few data are available on the influence of strenuous exercise on the content of circulating progenitor cells and especially the timeframe of their release. The aim of the present study was to investigate the potential influence of 4 hours of cycling on the time-dependent release of progenitor cells.


Condition Intervention
Healthy Men
 Behavioral: exercise training over 4 hours

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Time Dependent Mobilization of Circulating Progenitor Cells During Strenuous Exercise in Healthy Individuals.

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Leipzig:

Primary Outcome Measures:
  • Endothelial progenitor cells (EPC) release on [ Time Frame: 4 hours ] [ Designated as safety issue: No ]

Enrollment: 18
Study Start Date: September 2008
Study Completion Date: March 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise Training Behavioral: exercise training over 4 hours
Cycling over a period of 4 hours at 70% of max.
Other Name: exercise training

Detailed Description:
  1. What is the response of hematopoietic and endothelial progenitor cells after a standardized prolonged endurance exercise?
  2. What is the kinetic of cell mobilization during this standardized exercise?
  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy volunteers

Exclusion Criteria:

  • cardiovascular disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00900107

Locations
Germany
University Leipzig, Heart Center
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
University of Jena
Dep. of sports medicine
Investigators
Study Director: Gerhard C Schuler, Prof. Dr. Heart Center Leipzig
  More Information

No publications provided

Responsible Party: Dr. med. Sven Möbius-Winkler, Heart Center Leipzig
ClinicalTrials.gov Identifier: NCT00900107     History of Changes
Other Study ID Numbers: SMW 02
Study First Received: May 1, 2009
Last Updated: May 11, 2009
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

ClinicalTrials.gov processed this record on May 21, 2013