Study of Stored Tumor Samples in Young Patients With Brain Tumors
This laboratory study is looking at stored tumor samples in young patients with brain tumors. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
Brain and Central Nervous System Tumors
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas and Medulloblastoma/PNET of the Pediatric CNS|
- Relationship between molecular abnormalities and tumor histologic and clinical characteristics [ Time Frame: 10 Years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Fresh frozen, fixed and cultured tumor cells collected prospectively from a clinically well characterized patient cohort.
|Study Start Date:||November 2004|
|Estimated Study Completion Date:||November 2014|
|Estimated Primary Completion Date:||November 2014 (Final data collection date for primary outcome measure)|
Tumor material collected prospectively from a clinically well characterized patient cohort
The overall objective of this non-therapeutic protocol is to identify molecular abnormalities within prospectively treated pediatric CNS Atypical Teratoid Rhabdoid Tumors (ATRT), Choroid Plexus Carcinomas (CPC), and Ependymoma tumors and define the relationship between these abnormalities and tumor histologic and clinical characteristics. This objective will be achieved by applying state-of-the-art DNA, RNA and protein analysis tools to the study of fresh frozen, fixed and cultured tumor cells. The establishment of cell cultures from each tumor sample will also allow for in vitro analysis of tumor cell growth, signaling and therapeutic response.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00897286
|Contact: Tabatha E. Doyle, RNfirstname.lastname@example.org|
|United States, Tennessee|
|St. Jude Children's Research Hospital||Recruiting|
|Memphis, Tennessee, United States, 38105|
|Contact: Tabatha E. Doyle, RN 901-595-2544 email@example.com|
|Principal Investigator:||Amar Gajjar, MD||St. Jude Children's Research Hospital|
|Principal Investigator:||Richard J. Gilbertson, MD, PhD||St. Jude Children's Research Hospital|