Dasatinib and Bevacizumab in Treating Patients With Recurrent or Progressive High-Grade Glioma or Glioblastoma Multiforme

DISEASE CHARACTERISTICS:

• Histologically confirmed diagnosis of 1 of the following:

  • Grade 3 or 4 glioma, including astrocytoma, oligodendroglioma, and mixed gliomas (Phase I)
  • Glioblastoma* multiforme (grade 4 astrocytoma) (Phase II) NOTE: *Variant gliosarcomas are allowed

• Evidence of tumor recurrence or progression by MRI or CT scan following radiotherapy or most recent antitumor therapy

  • Patients who have had surgical treatment at recurrence are eligible if they had a subtotal resection with measurable or non-measurable residual disease on postoperative imaging or if there is imaging evidence of disease progression as compared to the first postoperative scan

• Bidimensionally measurable or evaluable disease by MRI or CT scan

  • Patients who have had a gross total resection (GTR) are eligible on the basis of evaluable disease
• No known pleural or pericardial effusion of any grade

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2
• ANC ≥ 1,500/mm^3
• Platelet count ≥ 100,000/mm^3
• Hemoglobin > 9.0 g/dL
• Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
• SGOT ≤ 3 times ULN
• Creatinine normal
• Urine protein:creatinine ratio < 1 or urine protein < 1,000 mg on 24-hour urine collection
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for ≥ 6 months after completion of study treatment
• Able to complete questionnaires with or without assistance
• Willing to return to NCCTG enrolling institution for follow-up
• Willing to provide mandatory tissue samples for research purposes
• QTc interval ≤ 450 msec
• No congenital long QT syndrome

• No uncontrolled hypertension (systolic BP of > 150 mm Hg or diastolic BP > 100 mm Hg on antihypertensive medications)

  • Well-controlled hypertension allowed
• No myocardial infarction or unstable angina within the past 6 months
• No NYHA class II-IV congestive heart failure
• No significant vascular disease (e.g., aortic aneurysm, aortic dissection) or recent peripheral arterial thrombosis within the past 6 months
• No history of any clinically significant ventricular arrhythmias (i.e., ventricular tachycardia, ventricular fibrillation, or Torsades de pointes)
• No stroke or transient ischemic attack within the past 6 months
• No history of hypertensive crisis or hypertensive encephalopathy
• No evidence of any CNS hemorrhage on baseline CT or MRI
• No co-morbid systemic illnesses or other severe concurrent disease that, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens

• No immunocompromised patients (other than that related to the use of corticosteroids)

  • Known HIV positivity without clinical evidence of an immunocompromised state allowed
• No condition (e.g., gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for IV alimentation or prior surgical procedures affecting absorption) that impairs ability to swallow pills
• No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months
• No evidence of bleeding diathesis (greater than normal risk of bleeding) or coagulopathy (in the absence of therapeutic anticoagulation)
• No active or recent history of hemoptysis (≥ ½ teaspoon of bright red blood per episode) within the past 30 days
• No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection or psychiatric illness or social situations that would limit compliance with study requirements
• No other active malignancy within the past 3 years except for nonmelanoma skin cancer or carcinoma in situ of the cervix
• No known hypersensitivity to any of the components of dasatinib or bevacizumab
• No significant traumatic injury within the past 28 days
• No serious nonhealing wounds, active ulcers, or untreated bone fractures
• No hypokalemia or hypomagnesemia that cannot be corrected prior to dasatinib administration

• Patients may not have any clinically significant cardiovascular disease including the following:

  • Myocardial infarction or ventricular tachyarrhythmia within 6 months
  • Prolonged QTc ≥ 480 msec (Fridericia correction)
  • Ejection fraction less than institutional normal
  • Major conduction abnormality (unless a cardiac pacemaker is present)

  • Patients with any cardiopulmonary symptoms of unknown cause (e.g., shortness of breath, chest pain, etc.) should be evaluated by a baseline echocardiogram with or without stress test as needed in addition to electrocardiogram (ECG) to rule out QTc prolongation

    • Patients with underlying cardiopulmonary dysfunction should be excluded from the study

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• Any number of prior chemotherapy regimens for recurrent disease allowed (Phase I)
• No more than 4 weeks since prior chemotherapy, small-molecule cell-cycle inhibitors, or other investigational agents (≥ 6 weeks since nitrosoureas) at the time of registration
• More than 1 week since prior aspirin or medications that inhibit platelet function
• No more than 2 prior chemotherapy regimens with ≤ 1 regimen for recurrent disease (Phase II)
• No prior bevacizumab or VEGF-Trap (Aflibercept)

• No prior intratumoral therapy, stereotactic radiosurgery, or interstitial brachytherapy except for the following:

  • Separate lesion on MRI that is not part of the previous treatment field
  • Evidence of recurrent disease based on biopsy, MRI spectroscopy, or PET scan
• At least 7 days since prior core biopsy or other minor surgical procedures (placement of a vascular access device is allowed)

• At least 7 days since prior drugs that have a risk of causing Torsades de Pointes, including any of the following:

  • Quinidine, procainamide, disopyramide
  • Amiodarone, sotalol, ibutilide, dofetilide
  • Erythromycin, clarithromycin
  • Chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide
  • Cisapride, bepridil, droperidol, methadone, arsenic, chloroquine, domperidone, halofantrine, levomethadyl, pentamidine, sparfloxacin, lidoflazine
  • Prochlorperazine
• At least 28 days since prior and no concurrent major surgical procedure or open biopsy
• At least 12 weeks since prior radiotherapy

• No concurrent therapeutic anticoagulation with warfarin, except low-dose warfarin for venous or arterial access devices, provided INR < 1.5

  • Therapeutic anticoagulation with low molecular weight heparin allowed
• No other concurrent investigational agent considered as a therapy for the primary neoplasm
• No concurrent therapy (other than hormonal therapy) for other prior malignancy
• No concurrent H_2 blockers or proton pump inhibitors that cannot be discontinued or switched to locally acting agents (i.e., famotidine, omeprazole, Maalox, Mylanta, or Tums)
• Use of the following enzyme-inducing anticonvulsive (EIAC) medications is prohibited ≤ 7 days prior to registration: carbemazepine (Tegretol®, Tegretol XR®, Carbatrol®), phenytoin (Dilantin®, Phenytek®), fosphenytoin (Cerebyx®), phenobarbital, pentobarbital, and primidone (Mysoline®)
• The following agents are not known to affect dasatinib metabolism and are acceptable for use: valproic acid (Depakote®, Depacon®), gabapentin (Neurontin®), lomotrigine (Lamictal®), topiramate (Topamax®), tiagabine (Gabitril®), zonisamid (Zonegram®), levetriacetam (Keppra®), clonazepam (Klonipin®), and clonozam (Frisium®)