Space Flight Simulation to Study Effects of Micro-gravity Through Bed Rest (FAP)

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2011 by National Aeronautics and Space Administration (NASA)
Sponsor:
Information provided by:
National Aeronautics and Space Administration (NASA)
ClinicalTrials.gov Identifier:
NCT00891449
First received: April 30, 2009
Last updated: October 5, 2011
Last verified: October 2011
  Purpose

Space flight simulation study to study effects of microgravity through bedrest coupled with flight exercise counter-measures.


Condition
Weightlessness

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Countermeasure and Functional Testing Study (CFT-70)

Further study details as provided by National Aeronautics and Space Administration (NASA):

Biospecimen Retention:   Samples Without DNA

Blood, Urine


Estimated Enrollment: 20
Study Start Date: July 2011
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Detailed Description:

Flight Analogs/Bed Rest Research Project (FA/BRRP) provides NASA with a ground-based research platform to complement space research. By mimicking on Earth the conditions of weightlessness experienced by the human body in space, NASA can test and refine scientific theories and procedures to develop countermeasures to protect humans from the effects of the space travel. The use of ground analogs, such as bed rest, are essential because access to the resources required to conduct studies in space is very limited, and the expense of studies significantly greater than those conducted using flight analogs. Future space exploration will challenge NASA to answer many critical questions about how humans can live and work for extended missions away from Earth.

Flight analog testing is critical to NASA to validate countermeasures, given the few opportunities to use flight platforms as the Shuttle retires; also, the US has only 1-2 International Space Station (ISS) crewmembers per Expedition. The Flight Analogs/Bed Rest Research Project is one way NASA will devise ways to ensure astronaut safety and productivity on extended missions to the moon and Mars.

In the Flight Analogs Project (FAP), volunteers spend many days in a controlled research environment in the Flight Analog Research Unit (FARU) in Galveston, TX. In the current campaigns, volunteers will undergo three phases in the bedrest projects: 1) pre-bedrest baseline testing, 2) a bedrest phase, and 3) the recovery period. Bed rest results in many physiologic changes similar to those seen in astronauts. Pre bed rest is used to gather baseline data against which the bed-rest phase data will be compared. Researchers then monitor how the volunteers' bodies change over the course of the study and how quickly they recover once they are allowed to resume normal activities. Post bed rest is used to monitor recovery from bed rest. In longer campaigns, return to the unit for follow-up testing may be requested after 1, 3, 6, and/or 12 months.

THE COUNTERMEASURE AND FUNCTIONAL TESTING STUDY (CFT) will test the effectiveness of exercise on loss of muscle, bone and cardiovascular function. Participants will perform an exercise program in a system called the standalone Zero Gravity Locomotion Simulator (sZLS), a "vertical treadmill" that removes the weight from the long axis of the body to simulate exercise as it is done in space. Resistance (weight lifting) exercise will be performed on special weight machines. Before and after 70 days of bedrest, participants will be tested on a corresponding set of physiological measures. Specific exercises and intensities are rotated such that each workout is different, with some days being heavier and some lighter. Results of the study will help understand which mission tasks might be affected by changes in physiology during space flight and design countermeasures to prevent or minimize impairment to these physiological systems

The ALTERNATE COMPRESSION GARMENT STUDY (ACG) will determine effectiveness of compression garments on regulating blood pressure and other body systems after extended periods of head-down bed rest. Participants in the experimental group will wear custom-fit compression garments and undergo evaluation on their response to an upright tilt test and a corresponding set of physiological measures before and after 14 days of bed rest. These participants will be compared to another group of participants who did not wear the compression garments. Results of the study will help scientists determine the time it takes for the cardiovascular system to re-adapt to upright posture, determine whether wearing compression garments during recovery is necessary to protect against dizziness and loss of consciousness often experienced after space missions, and determine the effect of wearing custom fit compression garments on the amount of time needed to readjust to a normal, upright posture.

  Eligibility

Ages Eligible for Study:   24 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Community sample

Criteria

Inclusion Criteria:

  • US Citizen
  • Must be able to pass physical

Exclusion Criteria:

  • tobacco use
  • menopausal
  • prescription drug use
  • food allergies
  • joint injuries
  • Thrombosis
  • Reflux
  • High blood pressure
  • Diabetes
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00891449

Locations
United States, Texas
University of Texas Medical Branch Recruiting
Galveston, Texas, United States, 77555
Contact: Wanda Thompson, RN, BC, NMCC    866-572-8378    wanda.thompson-1@nasa.gov   
Sponsors and Collaborators
National Aeronautics and Space Administration (NASA)
Investigators
Principal Investigator: Dr. Ronita L Cromwell, Ph.D. National Aeronautics and Space Administration (NASA)
  More Information

Additional Information:
No publications provided

Responsible Party: Ronita Cromwell, PhD, NASA
ClinicalTrials.gov Identifier: NCT00891449     History of Changes
Other Study ID Numbers: SA-06-2770
Study First Received: April 30, 2009
Last Updated: October 5, 2011
Health Authority: United States: Federal Government

Keywords provided by National Aeronautics and Space Administration (NASA):
space flight simulation study
medical research study
bed rest
microgravity
weightlessness
The effects of long duration microgravity on humans

ClinicalTrials.gov processed this record on October 23, 2014