The Efficacy of Doxazosin for Cocaine Users
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Purpose
Doxazosin, an alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. This study will evaluate the effectiveness of doxazosin in preventing drug relapse among cocaine dependent participants.
| Condition | Intervention | Phase |
|---|---|---|
|
Cocaine Dependence |
Drug: Doxazosin Drug: Placebo |
Phase 1 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | Doxazosin, An Alpha-1 Adrenergic Antagonist, for Cocaine Dependence: Pilot Study |
- Self reports of cocaine and other drug use and cravings [ Time Frame: throughout the study ] [ Designated as safety issue: No ]
- The urine drug screen results [ Time Frame: throughout the study ] [ Designated as safety issue: No ]
- Doxazosin will be well tolerated without significant side effects as we increased to our target dose of 8 mg Doxazosin daily [ Time Frame: throughout the study ] [ Designated as safety issue: Yes ]
| Enrollment: | 35 |
| Study Start Date: | September 2009 |
| Study Completion Date: | December 2011 |
| Primary Completion Date: | April 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Doxazosin
The starting dose will be 1 mg once daily at week 1 of the overall 17 week study, then 2 mg at week 2, with 1mg/week induction rate for 8 weeks. The target dose of 8 mg daily will probably not be attained by some patients over a 8 week induction period. We will try to increase their dose up to a minimum of 4 mg and optimum of 8 mg daily as daily dosing.
|
Drug: Doxazosin
The target dose of 8 mg will probably not be attained by some patients over a 8 week induction period (starting at week 1 of the overall 17 week study). We will try to increase the subjects' dose up to a minimum of 4 mg and optimum of 8 mg daily as once daily dosing. The starting dose will be 1 mg once daily at week 1, then 2 mg once daily at week 2, with 1mg/week induction rate for 8 weeks. They will be maintained on 4mg-8mg daily dosing until week 13. The subjects will be undergo the discontinuation from the study medication during weeks 14 -17.
Other Name: Cardura (Doxazosin Mesylate)
|
| Placebo Comparator: placebo |
Drug: Placebo
Placebo daily dosing
Other Name: sugarpills ( Capsules)
|
Detailed Description:
The NE system, especially the alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. The results of this study will provide medical safety data on the duration of the induction schedule that will be optimal for attaining our target dose of 8 mg doxazosin daily and will guide future pharmacotherapy trials using Doxazosin or related alpha 1 receptor antagonists for cocaine addiction.
This 17-week double-blind, placebo controlled clinical trial includes a 13 week medication trial (weeks 1-13) and up to 4 week washout period(weeks 14-17). Qualifying subjects will be randomized to receive Doxazosin 8 mg/day, or placebo during the study participation.
Subjects will be receiving 1 mg study medication/placebo capsules at week 1, with 1mg/week induction rate for 8 weeks, according to their randomized assignments, and are maintained on these agents through week 13. At the end of the study (weeks 14-17), participants will undergo discontinuation from active/placebo medication over a 4-week period. Subjects who wish to be transferred to an appropriate treatment program or treatment-research program will be helped with referral during the 4 week period (weeks 14-17).
Eligibility| Ages Eligible for Study: | 18 Years to 64 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Meets DSM-IV diagnosis criteria for cocaine dependence, as determined by self-reported use of cocaine at least once weekly for at least 1 month prior to study entry; a positive urine test for cocaine; and a score greater than 3 on the Severity of Dependence Scale
- If female, willing to use contraception throughout the study
Exclusion Criteria:
- Meets DSM-IV diagnosis criteria for dependence on any drugs other than cocaine, or tobacco
- Current major psychiatric illness, including schizophrenia, bipolar disorder, or other psychotic disorder
- Current suicidal or homicidal ideation
- Current use of a prescribed psychotropic medication that cannot be discontinued
- History of or current major medical illness, including major heart, kidney, endocrine, or liver disorder; abnormal liver function (SGOT or SGPT levels three times greater than normal); or high blood pressure or low blood pressure
- High risk factor for heart disease, seizure disorders, or any illness for which disulfiram or methadone treatment would be inadvisable
- Currently taking metronidazole or clotrimazole
- Pregnant or breastfeeding
Contacts and Locations| United States, Texas | |
| Baylor College of Medicine - Michael E. DeBakey VA Medical Center | |
| Houston, Texas, United States, 77030 | |
| Principal Investigator: | Thomas R Kosten, MD | Baylor College of Medicine |
More Information
No publications provided
| Responsible Party: | Thomas R. Kosten, MD, Professor, Baylor College of Medicine |
| ClinicalTrials.gov Identifier: | NCT00880997 History of Changes |
| Other Study ID Numbers: | NIDA-18197-4, P50DA018197-04, DPMC |
| Study First Received: | April 13, 2009 |
| Last Updated: | October 22, 2012 |
| Health Authority: | United States: Federal Government |
Keywords provided by Baylor College of Medicine:
|
Cocaine Dependence Substance Related Disorders |
Additional relevant MeSH terms:
|
Cocaine-Related Disorders Substance-Related Disorders Mental Disorders Cocaine Doxazosin Adrenergic Antagonists Vasoconstrictor Agents Cardiovascular Agents Therapeutic Uses Pharmacologic Actions Dopamine Uptake Inhibitors Dopamine Agents Neurotransmitter Agents |
Molecular Mechanisms of Pharmacological Action Neurotransmitter Uptake Inhibitors Physiological Effects of Drugs Anesthetics, Local Anesthetics Central Nervous System Depressants Sensory System Agents Peripheral Nervous System Agents Central Nervous System Agents Antihypertensive Agents Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Adrenergic Agents |
ClinicalTrials.gov processed this record on June 17, 2013