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Genetic Factors in Chronic Sinusitis

This study is currently recruiting participants.
Verified December 2012 by University of Chicago
Sponsor:
Information provided by (Responsible Party):
Jayant Pinto, University of Chicago
ClinicalTrials.gov Identifier:
NCT00880516
First received: April 9, 2009
Last updated: December 14, 2012
Last verified: December 2012
History of Changes
  Purpose

The purpose of this study is to learn more about the genetics of chronic sinusitis and identify genes involved in chronic sinusitis.


Condition
Chronic Sinusitis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Genetic Factors in Chronic Sinusitis

Resource links provided by NLM:

MedlinePlus related topics: Sinusitis
U.S. FDA Resources

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Association of genetic variation with CRS disease status [ Time Frame: Adult age ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

peripheral blood for DNA


Estimated Enrollment: 1200
Study Start Date: April 2009
Estimated Study Completion Date: March 2016
Estimated Primary Completion Date: March 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts
control
Adults with normal sinuses
case
Adults with chronic sinusitis and positive findings on imaging.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Adults with and without chronic sinusitis

Criteria

Inclusion Criteria:

  • Age> 18 years
  • Diagnosis of chronic sinusitis or normal sinuses (with verification by imaging.) You must have a recent CT scan showing either normal sinuses or the presence of sinus disease.

Exclusion Criteria:

  • Genetic or acquired immunodeficiency
  • Ciliary dyskinesia
  • Cystic fibrosis
  • Autoimmune disease
  • Cancer of the sinuses
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00880516

Contacts
Contact: Marcy deTineo, BSN 773-702-5889 mdetineo@surgery.bsd.uchicago.edu

Locations
United States, Illinois
University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Principal Investigator: Jayant Pinto, MD            
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: Jayant Pinto, MD University of Chicago
  More Information

No publications provided

Responsible Party: Jayant Pinto, Professor, University of Chicago
ClinicalTrials.gov Identifier: NCT00880516     History of Changes
Other Study ID Numbers: 16749A
Study First Received: April 9, 2009
Last Updated: December 14, 2012
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Sinusitis
Chronic Disease
Paranasal Sinus Diseases
Nose Diseases
Respiratory Tract Diseases
 Respiratory Tract Infections
Otorhinolaryngologic Diseases
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on June 17, 2013