Gut Hormone Secretion and Macronutrients
The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients after bariatric surgery.
The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.
Other: test meal
|Study Design:||Time Perspective: Prospective|
|Official Title:||Gut Hormone Secretion Pattern in Response to Different Macronutrients in Healthy Volunteers|
- Gut hormone secretion [ Time Frame: within 4 hours following a test meal ] [ Designated as safety issue: No ]
- Entero-insular axis measurement [ Time Frame: within 4 hours following a test meal ] [ Designated as safety issue: No ]
- Glucose turnover [ Time Frame: 6 hours ] [ Designated as safety issue: No ]
- Insulin sensitivity [ Time Frame: 6 hours ] [ Designated as safety issue: No ]
- Substrate oxidation [ Time Frame: 6 hours ] [ Designated as safety issue: No ]
|Study Start Date:||March 2009|
|Study Completion Date:||December 2009|
|Primary Completion Date:||August 2009 (Final data collection date for primary outcome measure)|
Other: test meal
Mixed meal containing bread, butter, beefOther: glucose
administration of a glucose mealOther: fat
administration of a lipid mealOther: protein
administration of a protein mealOther: control
The study is designed to asses the role of each individual macronutrient of a compete meal in gut hormones secretion in healthy volunteers.
8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test.
To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.
|Cardiomet Clinical research Center, CHUV|
|Lausanne, VD, Switzerland, CH-1011|
|University of Lausanne|
|Lausanne, Switzerland, 1005|
|Principal Investigator:||Luc Tappy, MD||Centre Hospitalier Universitaire Vaudois|