Obesity and the Initiation of Knee Osteoarthritis
Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120. The tests involve: 1 tube blood draw, 1 gait test (motion capture) and 1 MR of both knees.
|Study Design:||Observational Model: Ecologic or Community|
|Official Title:||Obesity and Initiation of Osteoarthritis|
- Knee MR cartilage wear, Gait knee adduction moment, COMP value in blood. [ Time Frame: baseline or first and only visit. ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
One tube of blood identified with a unique number.
|Study Start Date:||March 2009|
|Study Completion Date:||March 2012|
|Primary Completion Date:||March 2012 (Final data collection date for primary outcome measure)|
The tests will be done at the VA and Stanford and are not dangerous or painful. They are designed to help us learn more about the relationship of excess weight on cartilage degradation by testing a biomarker in blood. Gait testing involves walking in a lab that is about 20 meters long about 20 times. MR involves lying in a tube for less than 1 hour.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00856739
|United States, California|
|VA Palo Alto Health Care System|
|Palo Alto, California, United States, 94304-1290|
|Principal Investigator:||Thomas P. Andriacchi, PhD||VA Palo Alto Health Care System|