Impairments of Oral Language in Mobius Syndrome

This study has been completed.
Sponsor:
Information provided by:
Fortaleza University
ClinicalTrials.gov Identifier:
NCT00856531
First received: March 4, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted
  Purpose

The Möbius syndrome constitutes a congenital disorder classically caused by genetic and environmental factors. The clinical manifestations include lesion of the facial and abducens nerves associated with limb malformations specially club foot. The speech-language manifestations include compromise of oral and deglutition, speech and language functions, secondary to cranial nerves lesions and mental retardation. The language compromise in this disorder is still not well known. In this way, the main objective of this study is to characterize the oral language in a population of fifteen subjects with Möbius syndrome with age ranging from two to thirteen years old, from both sexes, seen in one of the three main center for genetic diagnosis in the state of Ceará. The present work is a descriptive study of a cross-sectional design conducted from February to December/2002, using a clinical evaluation of language components including morphology, syntax, semantics and pragmatics. The investigators identified exclusive speech involvement in 20,0% of the subjects, language disturbance in 46,7%, speech and language disturbance in 13,3% and oral language involvement in 26,7%. The investigators conclude that the language disturbance in the Möbius syndrome presents with a variable compromise of all oral language components. The delay in linguistical development, incomprehensive speech and the deficit of constructions of sentences and narrations are constant.


Condition
Möbius Sequence

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Impairments of Oral Language in Subjects With the Möbius Sequence

Resource links provided by NLM:


Further study details as provided by Fortaleza University:

Study Start Date: January 2002
Study Completion Date: January 2003
Primary Completion Date: January 2003 (Final data collection date for primary outcome measure)
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Detailed Description:

In this way, the main objective of this study is to characterize the oral language in a population of fifteen subjects with Möbius syndrome with age ranging from two to thirteen years old, from both sexes, seen in one of the three main center for genetic diagnosis in the state of Ceará. The present work is a descriptive study of a cross-sectional design conducted from February to December/2002, using a clinical evaluation of language components including morphology, syntax, semantics and pragmatics.

  Eligibility

Ages Eligible for Study:   3 Years to 16 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

fifteen subjects with Möbius syndrome with age ranging from two to thirteen years old, from both sexes, seen in one of the three main center for genetic diagnosis in the state of Ceará, Brazil.

Criteria

Inclusion Criteria:

  • Möbius syndrome
  • Age ranging from two to thirteen years old.

Exclusion Criteria:

  • Others diseases with impact in oral language.
  Contacts and Locations
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No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Renata Cavalcante Barbosa Haguette, Hospital Infantil Albert Sabin
ClinicalTrials.gov Identifier: NCT00856531     History of Changes
Other Study ID Numbers: mobius syndrome
Study First Received: March 4, 2009
Last Updated: March 4, 2009
Health Authority: Brazil: Ethics Committee

Keywords provided by Fortaleza University:
Möbius syndrome
Language
Speech, Language and Hearing Sciences

Additional relevant MeSH terms:
Mobius Syndrome
Facial Nerve Diseases
Cranial Nerve Diseases
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Infant, Newborn, Diseases

ClinicalTrials.gov processed this record on August 18, 2014