Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation

This study has been completed.
Sponsor:
Collaborator:
Vanderbilt University
Information provided by:
Kronos Longevity Research Institute
ClinicalTrials.gov Identifier:
NCT00847743
First received: February 17, 2009
Last updated: February 18, 2009
Last verified: February 2009
  Purpose

Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation.

Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives.

We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.


Condition Intervention
Oxidative Stress
Antioxidant Capacity
Inflammation
Dietary Supplement: Tart Cherry Juice

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Prevention
Official Title: Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women

Resource links provided by NLM:


Further study details as provided by Kronos Longevity Research Institute:

Primary Outcome Measures:
  • plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge. [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Urinary markers of oxidative damage. [ Designated as safety issue: No ]

Enrollment: 12
Study Start Date: October 2007
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Dietary Supplement: Tart Cherry Juice
    8 fl.oz. twice per day
    Other Name: CherryPharm
Detailed Description:

Objectives

The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.

  Eligibility

Ages Eligible for Study:   55 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • men and women, ages 55-80y, in good health, with >8 years of education
  • non-smoker
  • able to give informed consent

Exclusion Criteria:

  • use of anti-oxidant supplements, in excess of a standard multi-vitamins
  • current hormone replacement therapy
  • any history of significant chronic disease
  • uncontrolled hypertension
  • body mass index (BMI) > 30 kg/m2
  • high physical activity level, as determined by questions on the screening questionnaire
  • use of anti-inflammatory medication
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00847743

Locations
United States, Arizona
Kronos Longevity Research Institute
Phoenix, Arizona, United States, 85016
Sponsors and Collaborators
Kronos Longevity Research Institute
Vanderbilt University
Investigators
Principal Investigator: Tinna Traustadottir, Ph.D. Kronos Longevity Research Institute
  More Information

No publications provided by Kronos Longevity Research Institute

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Tinna Traustadóttir, Ph.D., Kronos Longevity Research Institute
ClinicalTrials.gov Identifier: NCT00847743     History of Changes
Other Study ID Numbers: KLRI-2007-03
Study First Received: February 17, 2009
Last Updated: February 18, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by Kronos Longevity Research Institute:
oxidative stress
aging
ischemia-reperfusion

Additional relevant MeSH terms:
Inflammation
Pathologic Processes

ClinicalTrials.gov processed this record on October 20, 2014