Effects of H1-Antagonist on Cognition
This study has been completed.
Sponsor:
Maastricht University Medical Center
Information provided by:
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT00846950
First received: February 17, 2009
Last updated: February 18, 2009
Last verified: February 2009
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Purpose
The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.
| Condition | Intervention |
|---|---|
|
Cognition |
Drug: dexchlorpheniramine, lorazepam |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Pharmacodynamics Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Basic Science |
| Official Title: | Effects of H1-Antagonist on Stages of Human Information Processing |
Resource links provided by NLM:
Further study details as provided by Maastricht University Medical Center:
Primary Outcome Measures:
- P300 latency and LRP onset latency [ Time Frame: 1.5 hours after treatment ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Words recalled [ Time Frame: 1.5 hours after treatment ] [ Designated as safety issue: No ]
| Enrollment: | 18 |
| Study Start Date: | December 2006 |
| Study Completion Date: | May 2007 |
| Primary Completion Date: | May 2007 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Experimental: healthy volunteers | Drug: dexchlorpheniramine, lorazepam |
Detailed Description:
The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.
Eligibility| Ages Eligible for Study: | 18 Years to 45 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Healthy as determined by a physician
Exclusion Criteria:
- present or history of any neurological of psychiatric disease
- present or history of any substance abuse
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00846950
Locations
| Netherlands | |
| Faculty of Psychology and Neuroscience, Maastricht University | |
| Maastricht, Limburg, Netherlands, 6229 ER | |
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
| Principal Investigator: | Annemiek Vermeeren, Ph.D. | Maastricht University hospital |
More Information
Additional Information:
No publications provided
| Responsible Party: | Effects of H1-antagonist on stages of human information processing, Dr. A. Vermeeren |
| ClinicalTrials.gov Identifier: | NCT00846950 History of Changes |
| Other Study ID Numbers: | 06-3-075 |
| Study First Received: | February 17, 2009 |
| Last Updated: | February 18, 2009 |
| Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Keywords provided by Maastricht University Medical Center:
|
H1-antagonist Event Related Potentials Memory Information processing The effects of an H1 antagonist (dexchlorpheniramine) on human cognition |
Additional relevant MeSH terms:
|
Lorazepam Dexchlorpheniramine Chlorpheniramine Anticonvulsants Central Nervous System Agents Therapeutic Uses Pharmacologic Actions Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs Anti-Anxiety Agents Tranquilizing Agents Psychotropic Drugs GABA Modulators |
GABA Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Antiemetics Autonomic Agents Peripheral Nervous System Agents Gastrointestinal Agents Histamine H1 Antagonists Histamine Antagonists Histamine Agents Anti-Allergic Agents Antipruritics Dermatologic Agents |
ClinicalTrials.gov processed this record on May 19, 2013