Effect of Local Injury on Implantation
Recruitment status was Recruiting
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Purpose
Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.
| Condition | Intervention | Phase |
|---|---|---|
|
Implantation Rate |
Procedure: local injury |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Effect of Local Injury to Endometrium on the Day of Oocyte Retrieval in First IVF Cycle on Implantation Rate. |
- implantation rate [ Time Frame: 4 weeks ] [ Designated as safety issue: Yes ]
- clinical pregnancy rate [ Time Frame: 4 weeks ] [ Designated as safety issue: Yes ]
| Estimated Enrollment: | 120 |
| Study Start Date: | June 2008 |
| Estimated Study Completion Date: | August 2009 |
| Primary Completion Date: | November 2008 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: local ingury
In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed.
|
Procedure: local injury
In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed
Other Name: it does not have other name
|
|
No Intervention: control
in 60 patients routine IVF are performed
|
Detailed Description:
Low implantation rate is still a major concern in ART cycles. It has been reported that local injury to endometrium may improve endometrial receptivity and implantation rate. A total of 120 patients in first IVF cycles, who are stimulated with long protocol, are randomly divided into two groups. In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed and in the other group no interventions are done. After fresh embryo transfers, implantation and clinical pregnancy rates are compared between two groups.
Eligibility| Ages Eligible for Study: | up to 35 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Age < 35
- First IVF cycle
- Long protocol should be used for stimulation
Exclusion Criteria:
- Day 3 FSH > 10
Contacts and Locations| Contact: Homa Oskouian, MD | 8247085 ext +98351 | homaoskouian@gmail.com |
| Contact: Mohamad ali karimzade, Prof | 8247087 ext +98351 | prof_karimzade@yahoo.com |
| Iran, Islamic Republic of | |
| Research and clinical center for infertility | Recruiting |
| Yazd, Iran, Islamic Republic of | |
| Contact: homa oskouian, m.d. 9151119558 ext +98 homaoskouian@gmail.com | |
| Contact: mohamad ali karimzadeh, prof. 8247085 ext +985351 prof._karimzadeh@yahoo.com | |
| Principal Investigator: homa oskouian, MD | |
| Principal Investigator: mohamad ali karimzade, prof | |
| Principal Investigator: | homa oskouian, M.D. | Research and clinical center for infertility |
| Principal Investigator: | Mohamad ali karimzade, MD | Research and clinical center for infertility |
More Information
No publications provided
| Responsible Party: | Mohmad ali karimzade, Research and clinical center for infertility |
| ClinicalTrials.gov Identifier: | NCT00846183 History of Changes |
| Other Study ID Numbers: | local injury111 |
| Study First Received: | February 17, 2009 |
| Last Updated: | January 19, 2010 |
| Health Authority: | Iran: Ministry of Health |
Keywords provided by Yazd Research & Clinical Center for Infertility:
|
local injury implantation rate endometrial receptivity IVF |
ClinicalTrials.gov processed this record on June 17, 2013