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Brain Electrophysiological Patterns in Obesity

This study has been completed.
Sponsor:
Information provided by:
Centre de Recherche en Nutrition Humaine Rhone-Alpe
ClinicalTrials.gov Identifier:
NCT00842569
First received: February 11, 2009
Last updated: NA
Last verified: February 2009
History: No changes posted
  Purpose

There is growing evidence of behavioural and neurobiological overlaps between obesity and drug abuse. Reduction of the amplitude of P300, a component of event-related potentials (ERP) elicited by an oddball paradigm, is an electrophysiological characteristic and a marker of vulnerability in substance abuse. We want to determine whether obesity is associated with such electrophysiological features during an auditory oddball paradigm. We postulate that obesity could be associated with electrophysiological abnormalities that could be viewed as a possible vulnerability marker for food addiction.


Condition
Obesity

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: ERP Study of Brain Electrophysiological Patterns in Obesity

Resource links provided by NLM:

MedlinePlus related topics: Obesity
U.S. FDA Resources

Further study details as provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:

Primary Outcome Measures:
  • Evaluation of amplitudes and latencies of the P300 complex of Event Related Potential during an oddball paradigm, in normal-weighted and obese subjects [ Designated as safety issue: No ]

Enrollment: 69
Study Start Date: January 2008
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
Normal weighted
BMI<25
Obese
BMI>30

  Eligibility

Ages Eligible for Study:   20 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

a healthy but normal-weighted or obese population. Depressive state or eating disorders were carefully evaluated.

Criteria

Inclusion Criteria:

  • The inclusion criteria for the study are men and women aged 20-60 years, BMI 18.5-24.9 kg/m2 for control subjects and BMI>30 kg/m2 for obese subjects, stable body weight over the previous 3 months, report of sedentary or moderate physical activity

Exclusion Criteria:

  • The exclusion criteria are pregnancy, post-menopausal women, any physiological or psychological illness that could influence the results, subjects likely to take medical drugs interfering with the electrophysiological parameters of the study, diabetes, hearing disorder, intense physical activity and report or evidence of excessive alcohol consumption, depressive state or eating disorders according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00842569

Locations
France
Centre de Recherche en Nutrition Humaine Rhone Alpes
Lyon, France, F69008
Sponsors and Collaborators
Centre de Recherche en Nutrition Humaine Rhone-Alpe
Investigators
Principal Investigator: Emmanuel DISSE, MD CRNH Rhone-Alpes
  More Information

Publications:

Responsible Party: Dr Emmanuel DISSE, Centre de Recherche en Nutrition Humaine Rhone-Alpe
ClinicalTrials.gov Identifier: NCT00842569     History of Changes
Other Study ID Numbers: CRNHRA-09-001
Study First Received: February 11, 2009
Last Updated: February 11, 2009
Health Authority: France: Direction Générale de la Santé

Keywords provided by Centre de Recherche en Nutrition Humaine Rhone-Alpe:
obesity
cognitive process
reward
P300
 ERP
Event-related potential during oddball paradigm
brain electrophysiological patterns
externalizing factor

Additional relevant MeSH terms:
Obesity
Overnutrition
Nutrition Disorders
 Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on May 23, 2013