Clopidogrel Efficacy and Acute Coronary Syndromes
The purpose of this study is to compare clopidogrel effectiveness between severe hemodynamically unstable versus stable patients with acute myocardial infarction.
Acute Myocardial Infarction
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||The Comparison of Clopidogrel Efficacy in Patients With Acute Myocardial Infarction and Severe Hemodynamic Instability to Patients With Hemodynamically Uncomplicated Myocardial Infarction|
- Lower efficacy of clopidogrel determined by VASP measurement [ Time Frame: 6 months ] [ Designated as safety issue: No ]
- Higher frequency of stent thrombosis in the unstable group [ Time Frame: 6 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||June 2006|
|Study Completion Date:||December 2008|
Patient with acute myocardial infarction plus severe hemodynamical instability. It means, on mechanical ventilation and catecholamine support
Patients with myocardial infarction hemodynamically completely (Killip I)stable.
Clopidogrel exists in oral form only. As a prodrug, it has to be metabolized to the active form by cytochrome system in the liver. Both facts could lead to lower efficacy of the drug in hemodynamically unstable patients, where splanchnic and liver hypoperfusion is present. We hypothesised that clopidogrel efficacy is insufficient in patients with acute myocardial infarction and severe hemodynamic instability. Therefore we would like to compare the effect of clopidogrel in unstable STEMI patients on mechanical ventilation with stable STEMI patients.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00839267
|Cardiocenter, 3rd Medical School, Charles University and University Hospital Kralovske Vinohrady|
|Prague, Czech Republic, 10034|
|Principal Investigator:||Pavel Osmancik, MD, PhD||Charles University Prague|