Retinal Function in Diabetic Patients Without Retinopathy (NEURODIAB)
The primary purpose was to assess, in diabetic patients without diabetic retinopathy and control subjects, color vision, contrast sensitivity, electroretinography, and flicker-induced vasodilatation using the Dynamic Vessel Analyzer, in order to specify the earliest impaired retinal cells in diabetes, and gain more insight into diabetic retinopathy pathogenesis.
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Assessment of Retinal Functional Abnormalities in Diabetic Patients Without Retinopathy|
|Study Start Date:||May 2005|
|Study Completion Date:||May 2007|
|Primary Completion Date:||January 2007 (Final data collection date for primary outcome measure)|
Diabetic patients without diabetic retinopathy : No intervention
Sex and age-matched control subjects : No intervention
Type 1 and type 2 diabetic patients with no diabetic retinopathy and no hypertension were compared with sex and age-matched control subjects. Color vision was tested with the desaturated LANTHONY 15-Hue test. Contrast sensitivity was assessed with the Pelli-Robson contrast sensitivity test. Pattern-electroretinogram, Ganzfeld full-field electroretinogram and multifocal electroretinogram were recorded according to the International Society for Clinical Electrophysiology of Vision (ISCEV). Flicker-induced vasodilatation in retinal arteries and veins was assessed using the Dynamic Vessel Analyzer.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00839150
|Paris, France, 75010|
|Principal Investigator:||Pascale Massin, MD,Pr;PhD||Assistance Publique - Hôpitaux de Paris|