Measurement of the Folate Receptor in Blood

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2009 by Royal Marsden NHS Foundation Trust.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Royal Marsden NHS Foundation Trust
ClinicalTrials.gov Identifier:
NCT00838747
First received: September 5, 2008
Last updated: February 5, 2009
Last verified: February 2009
  Purpose

The folate receptor (FR) is a cell marker that is over expressed on the cell surface of certain cancers, this occurs most frequently in ovarian cancers. Some normal tissues also express the FR, however in these normal tissues the FR is usually located on the tissue surface that is inaccessible to circulating drugs. As such, drugs which target the FR may potentially be used to achieve anti-tumour efficacy whilst reducing toxicity to normal tissues. Therefore the ability to measure FR levels from different cancer types may help to select patients who are most likely to benefit from treatment with FR targeted therapies. One such drug BGC 945 is currently being tested in preclinical study at The Institute of Cancer Research


Condition
Healthy

Study Type: Observational
Official Title: Measurement of the Folate Receptor in Blood

Resource links provided by NLM:


Further study details as provided by Royal Marsden NHS Foundation Trust:

Primary Outcome Measures:
  • To measure the levels of folate receptor in blood samples obtained from patients with ovarian cancer and from healthy volunteers [ Designated as safety issue: No ]

Estimated Enrollment: 27
Study Start Date: September 2008
Estimated Study Completion Date: July 2011
Estimated Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Detailed Description:

A method has been developed in the laboratory which has been able to measure FR obtained from cancer cells in culture that has been added into blood. We would like to study if this method can measure FR in plasma and serum obtained from patients with ovarian cancer. We would also like to analyse plasma and serum samples obtained from healthy volunteers to determine if they have any appreciable levels of FR, which can then be compared to the measurements obtained from cancer patients.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients with stage III/IV ovarian cancer
  • healthy volunteers who are staff at the ICR and RMH

Exclusion Criteria:

  • patients or healthy volunteers who are unable to give informed consent
  • pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00838747

Contacts
Contact: Stan Kaye 020 8661 3539 stan.kaye@rmh.nhs.uk
Contact: Matthew Ng 020 8661 3539 matthew.ng@icr.ac.uk

Locations
United Kingdom
Royal Marsden NHS Foundation Trust Recruiting
London, Sutton, United Kingdom, SM2 5PT
Contact: Stan Kaye    020 8661 3539    stan.kaye@rmh.nhs.uk   
Contact: Matthew Ng    020 8661 3539    matthew.ng@icr.ac.uk   
Principal Investigator: Stan Kaye         
Royal Marsden NHS Foundation Trust Recruiting
London, Sutton, United Kingdom, SM2 5PT
Contact: Prof Stan Kaye    020 86613538    stan.kaye@rmh.nhs.uk   
Contact: Dr Matthew Ng    020 86613538    matthew.ng@icr.ac.uk   
Principal Investigator: Prof Stan Kaye         
Sponsors and Collaborators
Royal Marsden NHS Foundation Trust
Investigators
Principal Investigator: Stan Kaye, Professor Royal Marsden NHS Foundation Trust
  More Information

No publications provided

Responsible Party: Professor Stan Kaye, Royal Marsden NHS Foundation Trust
ClinicalTrials.gov Identifier: NCT00838747     History of Changes
Other Study ID Numbers: CCR3028
Study First Received: September 5, 2008
Last Updated: February 5, 2009
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by Royal Marsden NHS Foundation Trust:
folate receptor
blood samples
ovarian cancer
development of measure of folate receptor in blood samples
possible selection of patients for treatment with FR targeted agents

Additional relevant MeSH terms:
Folic Acid
Vitamin B Complex
Vitamins
Micronutrients
Growth Substances
Physiological Effects of Drugs
Pharmacologic Actions
Hematinics
Hematologic Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on July 28, 2014