Endometrial Local Injury and Implantation Failure
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Purpose
The purpose of this study is to evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. The results suggest that in vitro fertilization or intracytoplasmic sperm injection after endometrial biopsy increase pregnancy outcome.
| Condition | Intervention |
|---|---|
|
Infertility |
Procedure: Endometrial biopsy Procedure: Endometrial Biopsy |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Subject) Primary Purpose: Treatment |
| Official Title: | Endometrial Local Injury Improves the Pregnancy Rate Among Recurrent Implantation Failure Patients Undergoing IVF/ICSI |
- Implantation Rate,Chemical pregnancy rate, Clinical pregnancy rate [ Time Frame: One year ] [ Designated as safety issue: Yes ]
| Enrollment: | 115 |
| Study Start Date: | January 2008 |
| Study Completion Date: | December 2008 |
| Primary Completion Date: | November 2008 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Biopsy catheter
Biopsy catheter (Pipelle de Cornier, Prodimed, Neuilly-en-Thelle, France
|
Procedure: Endometrial biopsy
Endometrial biopsy was done at luteal phase on the day 21-26 of spontaneous menstrual cycles, when GnRH agonist uses begun. Endometrial samples were taken by a biopsy catheter
Other Name: biopsy catheter (Pipelle de Cornier, Prodimed, France
Procedure: Endometrial Biopsy
Biopsy catheter
Other Name: Pipelle de Cornier, Prodimed, Neuilly-en-Thelle, France
|
Detailed Description:
In a randomized control trial study, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group.
The implantation rate was determined as 10.9% in biopsy group compared with 3.38% in controls. Clinical pregnancy rate was significantly higher in case group than controls (27.1% and 8.9% respectively
Eligibility| Ages Eligible for Study: | 15 Years to 39 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- women with recurrent implantation failure which was defined as 2-6 cycles unsuccessful of IVF-ET in which more than 10 high grade embryo were transferred
Exclusion Criteria:
- age over than 40 years old
- poor responders to ovarian stimulation
Contacts and Locations| Iran, Islamic Republic of | |
| Research and Clinical Center for Infertility | |
| Yazd, Iran, Islamic Republic of, 8916877391 | |
| Principal Investigator: | Mohammad Ali Karimzadeh, Professor | Research and Clinical Center for Infertility |
More Information
No publications provided
| Responsible Party: | Department of Obstetrics and Gynecology, Yazd Research & Clinical Center for Infertility |
| ClinicalTrials.gov Identifier: | NCT00837733 History of Changes |
| Other Study ID Numbers: | 1551354 |
| Study First Received: | February 4, 2009 |
| Last Updated: | February 4, 2009 |
| Health Authority: | Iran: Ministry of Health |
Keywords provided by Yazd Research & Clinical Center for Infertility:
|
Endometrial biopsy IVF/ICSI Pregnancy outcome Recurrent implantation failure |
Additional relevant MeSH terms:
|
Infertility Adenoma Genital Diseases, Male Genital Diseases, Female |
Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms |
ClinicalTrials.gov processed this record on May 23, 2013