Maternal Serum Cytokine Levels and Angiogenic Factor Levels in IVF vs Spontaneously Conceived Pregnancies
Recruitment status was Recruiting
The objective of the study is to compare maternal levels of cytokines and angiogenic factors in IVF vs spontaneously conceived singleton pregnancies. The null hypothesis is that there will be no significant difference.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Maternal Serum Cytokine Levels and Angiogenic Factor Levels in Singleton IVF Pregnancies vs Spontaneously Conceived Pregnancies|
- sFlt, human endoglin, PlGF, VEGF, IL-1, IL-2, IL-1ra, IL-4, IL-5, EGF, IL-6, Human IL-7, TGF, Fractalkine, IL-8, IL-10, IL-12p70, IL-13, IL-15, IL-17, IL-1, IFN-gamma, G-CSF, GM-CSF, TNF, Eotaxin, MCP-1, sCD40L, IL-12p40, MIP-1, MIP-1ß, IP-10 [ Time Frame: 10 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Maternal blood draws are to be performed at four times. These are 10-15 weeks, 22-28 weeks, 34-40 weeks, and 4-8 weeks postpartum. Additionally, placental biopsies and umbilical cord blood specimens are to be collected for possible future analysis.
|Study Start Date:||June 2008|
|Estimated Study Completion Date:||June 2010|
|Estimated Primary Completion Date:||March 2010 (Final data collection date for primary outcome measure)|
Pregnancies conceived with the use of assisted reproductive technologies. This is defined as a pregnancy conceived with all gametes being handled outside of the body.
Spontaneously conceived pregnancies.
Show Detailed Description
Please refer to this study by its ClinicalTrials.gov identifier: NCT00837278
|Contact: Christine Preslicka, RNfirstname.lastname@example.org|
|United States, California|
|Long Beach, California, United States, 90806|
|Contact: Christine Preslicka, RN 562-933-2755 email@example.com|
|Contact: Robert M Ehsanipoor, MD 562-933-2755 firstname.lastname@example.org|
|Principal Investigator: Kenneth Chan, MD|
|Principal Investigator:||Kenneth Chan, MD||MemorialCare|