Relapsed and/or Refractory Non-Hodgkin Lymphoma Study (COMBOSTAT)

This study has been withdrawn prior to enrollment.
Sponsor:
Information provided by:
The Methodist Hospital System
ClinicalTrials.gov Identifier:
NCT00837174
First received: February 3, 2009
Last updated: June 13, 2012
Last verified: June 2012
  Purpose

The purpose of this study is to determine the rate of response to the drugs bortezomib (Velcade) and vorinostat (Zolinza), when used in combination, in patients with relapsed (recurrent) and/or refractory (difficult to treat) non-Hodgkin Lymphoma, and to determine the safety and tolerability of this regimen.


Condition Intervention Phase
Non-Hodgkin Lymphoma
Drug: Vorinostat in combination with Bortezomib
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase II Study of Combination Vorinostat and Bortezomib in Patients With Relapsed and/or Refractory Non-Hodgkin Lymphoma

Resource links provided by NLM:


Further study details as provided by The Methodist Hospital System:

Primary Outcome Measures:
  • Determine the response rate of this regimen in this patient population. [ Time Frame: 6 cycles ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Determine the progression free survival of this regimen in this patient population. [ Time Frame: entire length of study ] [ Designated as safety issue: No ]
  • Determine the safety and tolerability of this regimen in this patient population. [ Time Frame: throughout course of study ] [ Designated as safety issue: Yes ]
  • To correlate response rate and progression free survival with pre-treatment and post-treatment NFkB, TRAIL, cyclin D1, histone acetylation, EBV related proteins, and CTA expression. [ Time Frame: 6 cycles ] [ Designated as safety issue: No ]

Enrollment: 0
Study Start Date: June 2010
Estimated Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Combination Vorinostat + Bortezomib
Six cycle combination therapy with vorinostat and bortezomib.
Drug: Vorinostat in combination with Bortezomib
Patients will be treated with oral vorinostat on days 1 through 14 followed by a 7-day rest period, for a 21-day treatment cycle for up to 6 cycles in the absence of disease progression or unacceptable toxicity. The patients will receive once-daily oral vorinostat (400 mg) with bortezomib 1.3 mg/m2 as an IV push on days 1, 4, 8, 11.
Other Names:
  • vorinostat (Zolinza)
  • bortezomib (Velcade)

Detailed Description:

More selective and less toxic therapeutic strategies are needed to improve cure rates and prolong survival in patients with relapsed and/or refractory non-Hodgkin Lymphoma.

Amongst the multiple new pathways recently studied two have emerged as potentially important targets for new agents in lymphoma. These include the ubiquitin proteasome pathway and the biochemical reactions that control histone acetylation. The first two agents in each class to have been studied in lymphomas are: bortezomib and vorinostat. Bortezomib has been granted FDA approval for the treatment of mantle cell lymphoma and has established activity in a variety of B-cell lymphomas including follicular, marginal zone and diffuse large B-cell lymphoma. Vorinostat or SAHA (suberoylanilide hydroxamic acid) has been FDA approved for the treatment of refractory cutaneous T-cell lymphomas and has also shown activity in other lymphomas.

Synergistic activity between vorinostat and bortezomib has been observed in different cell lines. The proposed study will be a phase II trial of the combination of vorinostat and bortezomib at the recommended dose-schedule in patients with recurrent and/or refractory lymphomas, indolent and aggressive, and B or T.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Histologically confirmed non-Hodgkin Lymphoma including small lymphocytic lymphoma, lymphoplasmacytic lymphoma, follicular center cell lymphoma, mantle cell lymphoma, marginal zone lymphoma, diffuse large B cell lymphoma, Burkitt's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma, nasal NK/T cell lymphoma, mycosis fungoides/Sezary syndrome, angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphomas not otherwise specified
  • Received 2 or > prior therapies, which may include hematopoietic cell transplant (HCT)
  • Received treatment with a nucleoside analog, or an alkylating agent, an anthracycline and/or in the case of B cell lymphomas, rituximab
  • Resistant disease to 2 regimens or resistant disease to at least 1 regimen after first relapse
  • Bi-dimensionally measurable disease documented within 30 days prior to enrollment. Bidimensionally measurable disease is defined as:

    • A lymph node or tumor mass that can be accurately measured in two dimensions by CT,MRI, medical photograph (skin or oral lesion), plain X-ray, PET scan or other conventional technique and a greatest diameter of 1 cm or >; or palpable lesions with both diameters > 2 cm (lesion measured in 2 largest perpendicular dimensions in millimeters)
    • For the purposes of this protocol, disease should be located in an area of no prior radiation therapy or a clear progression in an area that was previously irradiated
  • Adequate organ and marrow function obtained < or = to 14 days prior to enrollment as defined by a(n):

    • ANC > or = to 1,000/microliter
    • Platelet count > or = to 100,000/microliter, or > or = to 75,000/microliter if the bone marrow is involved
    • Hemoglobin level > or = to 9 g/dL
    • Total bilirubin < or = to 1.5 x institutional upper limit of normality (ULN).(If abnormal, direct bilirubin less than or equal to 1.5 x institutional ULN)
    • ALT or AST < or = to 2.5 x institutional ULN (< or = to 5 x institutional ULN if liver involvement with lymphoma)
    • Serum creatinine < or = to 1.5 x institutional ULN
  • Zubrod (ECOG) Performance Status of 0 or 1
  • Age > than or = to 18 years
  • Life expectancy > or = to 3 months as clinically determined by referring physician
  • Female patient is either post menopausal, free from menses for > 2 years, surgically sterilized or willing to use highly effective methods of contraception (i.e., a condom in conjunction with a diaphragm, or spermicidal jelly; or oral, injectable, or implanted birth control; or abstinence ) to prevent pregnancy throughout the study, starting with visit 1
  • Female patients of childbearing potential must have a negative serum pregnancy test (beta-HCG) within 72 hours of enrollment and should not be nursing due to the potential for congenital abnormalities and of harm to nursing infants due to this treatment regimen
  • Male patient agrees to use an adequate method of contraception (i.e., a condom if female partner uses a diaphragm, spermicidal jelly; or oral, injectable, or implanted birth control; or abstinence) for the duration of the study and for 12 weeks after the last dose
  • Patient must be able to swallow capsules
  • Signed and dated IRB/ethics committee-approved informed consent before any protocol specific screening procedures are performed
  • Both men and women of all races and ethnic groups are eligible for this trial

Exclusion Criteria:

  • Prior investigational therapy within 3 weeks of enrollment. Investigational therapy is defined as treatment that is not approved for any indication
  • CNS metastases, as indicated by clinical symptoms,cerebral edema, requirement for corticosteroids and/or progressive growth (treated CNS metastases must be stable for greater than 2 weeks prior to enrollment)
  • Active second malignancy that requires treatment or that would interfere with assessment of response
  • Prior malignancy, except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer with < 5 years of documented disease-free status
  • Treatment with the following within the timeframe specified prior to enrollment:

    • Chemotherapy, radiotherapy, immunotherapy (active (such as vaccines) or passive (such as monoclonal antibodies or immunotoxins)) or major surgery < or = to 3 weeks;
    • Nitrosourea, or mitomycin < or = to 6 weeks
    • Radioimmunotherapy (e.g. Bexxar or Zevalin) < or = to 12 weeks
    • Concurrent enzyme-inducing anticonvulsant agents or valproic acid in last 4 weeks
    • Prior bortezomib or any other proteasome inhibitor
    • Prior vorinostat or any other histone deacetylase inhibitor
    • Concurrent systemic corticosteroids (<10 mg/day of prednisone or equivalent for adrenal insufficiency or acute allergic reactions allowed)
  • Uncontrolled current illness including, but not limited to:

    • Clinically or laboratory determined active infection
    • Clinically limiting congestive heart failure or ejection fraction (EF) <45%
    • Clinically unstable angina pectoris (or myocardial infarction within 6 months of Day 1)
    • Clinically significant cardiac arrhythmia
    • Limiting pulmonary hypertension
    • Pre-existing neuropathy ≥ grade 2
    • Patients with pleural effusions, ascites or peripheral edema grade 2 or >
  • HIV
  • Active viral hepatitis
  • Major surgery or significant traumatic injury within 21 days prior to enrollment (this does not apply to placement of a venous access device)
  • Hypersensitivity to any of the components in vorinostat or bortezomib or agents containing boron or mannitol
  • Significant psychiatric illness/social situations that would limit compliance with study medication and requirements of the study as determined by study MD
  • Significant medical illness or abnormal laboratory finding that would, in the investigator's judgment, increase the subject's risk by participating in this study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00837174

Sponsors and Collaborators
The Methodist Hospital System
Investigators
Principal Investigator: Hector A Preti, M.D. The Methodist Hospital System
  More Information

No publications provided

Responsible Party: H. Alejandro Preti, M.D. / Principal Investigator, The Methodist Hospital System
ClinicalTrials.gov Identifier: NCT00837174     History of Changes
Other Study ID Numbers: 0908-0284
Study First Received: February 3, 2009
Last Updated: June 13, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by The Methodist Hospital System:
non-Hodgkin Lymphoma
aggressive lymphoma
indolent lymphoma
B cell lymphoma
T cell lymphoma
Diffuse large B cell lymphoma
anaplastic large B cell lymphoma
lymphoblastic lymphoma
Burkitt's lymphoma
transformed follicular center cell lymphoma
transformed marginal zone lymphoma
transformed small lymphocytic lymphoma
grade 3 follicular center cell lymphoma
blastic form marginal zone lymphoma
transformed cutaneous T cell lymphoma
mycosis fungoides stage IV
angioimmunoblastic lymphadenopathy-like T-cell lymphoma
nasal NK/T cell lymphoma
peripheral T-cell lymphoma
small lymphocytic lymphoma
lymphoplasmacytic lymphoma
follicular center cell lymphoma grade 1
follicular center cell lymphoma grade 2
mantle cell lymphoma
marginal zone lymphoma
mycosis fungoides

Additional relevant MeSH terms:
Lymphoma, Non-Hodgkin
Lymphoma
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Bortezomib
Vorinostat
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Histone Deacetylase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on September 16, 2014